Browsing Microbiology and Cell Biology (MCB) by Title
Now showing items 149-168 of 310
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Molecular characterisation of Saccharomyces cerevisiae Prp17protein and its interacting partners
In majority of eukaryotic genes, removal of intervening sequences from pre?mRNA is essential for its expression. A ribonucleoprotein complex called the spliceosome catalyses the removal of intron by two sequential ... -
Molecular Characterisation Of The ATP Binding Cassette (ABC) Transporter Type FtsE And FtsX Proteins Of Mycobacterium Tuberculosis
(2008-09-30)Mycobacterium tuberculosis, the principal causative agent of tuberculosis (TB) in humans, is considered to be a successful pathogen owing to the elicitation of multidrug resistance, ability to survive inside macrophage ... -
Molecular Genetic Analysis Of Flower Development In Rice
(2011-12-12) -
Molecular Genetic Analysis of Trichome Development in Arabidopsis thaliana
Several mutants with aberrant trichome patterning and differentiation are known in Arabidopsis. The genes involved in these processes code for proteins with diverse functions such as transcription, protein degradation, ... -
Molecular Genetic Studies On Pre-mRNA Splicing Factors Of Fission And Budding Yeasts
(2010-10-05)Nuclear pre-mRNA splicing proceeds via two mechanistically conserved consecutive trans-esterification reactions catalyzed by the spliceosome. The ordered coalescence of spliceosomal snRNPs and splicing factors on the ... -
Molecular insights into the regulation of host unfolded protein response and angiogenesis during Mycobacterium tuberculosis pathogenesis
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), continues to co-evolve with the human population, rendering it one of the most significant global health threats among infectious diseases. The ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ... -
Mycobacterial DNA gyrase : biochemical characterisation and development of a novel gyrase inhibitor
Synopsis DNA gyrase is a unique topoisomerase, as it is the only enzyme capable of introducing negative supercoils into DNA. The enzyme has essential roles in cellular DNA transactions such as DNA replication, transcription, ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Mycobacterium smegmatis topoisomerase I : insights into site specific recognition and mechanism of action
Mycobacterium smegmatis TOPOISOMERASE I: INSIGHTS INTO SITE-SPECIFIC RECOGNITION AND MECHANISM OF ACTION The work embodied in this thesis is an attempt to understand the relaxation mechanism catalyzed by Mycobacterium ... -
New Active Site Fold And The Role Of Metal Ions In Structure Function Relationship Of A Promiscuous Endonuclease - R.KpnI
(2010-07-08)Bacteria employ survival strategies to protect themselves against foreign invaders, including bacteriophages. The ‘immune system’ of bacteria relies mostly on restriction-modification (R-M) systems. The primary role of R-M ... -
Nitrate metabolism in yeasts studies on regulation and properties of nitrate reductase in Candida utilis. Ph.D. Thesis
Synopsis of the thesis entitled “NITRATE METABOLISM IN YEASTS: STUDIES ON REGULATION AND PROPERTIES OF NITRATE REDUCTASE IN CANDIDA UTILIS” submitted by V. P. Choudary Microbiology & Cell Biology Laboratory for the award ... -
Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics
(2009-04-15)Notch receptors and ligands are type I transmembrane proteins that regulate development and differentiation during cell-cell contact. There are four Notch receptor homologues and five notch ligands, identified in humans ... -
Nucleoid-associated Proteins of Mycobacterium tuberculosis : Insights into their Functions
Bacteria face the challenging task of compacting their chromosomes to accommodate them in a small cytoplasmic volume and at the same time maintaining the nucleoids in a highly organized and dynamic state for transcription, ... -
Panoramic View of RNA Binding Proteins (RBPs) in Glioblastoma : IMP3, an RBP, is Essential for Glioma Stem-like Cell Maintenance
Gliomas are primary brain tumors in adults that are believed to originate from different types of glial cells. Central nervous system gliomas pose particularly difficult problems because of their tendency towards malignancy, ... -
Phosphoprotein P of rinderpest virus : Its role in the virus life cycle
Phosphoprotein P of Rinderpest Virus: A Key Player in the Virus Life Cycle Introduction Negative-strand RNA viruses (NNSVs) are enveloped viruses infecting hosts across the animal and plant kingdoms. They exhibit diverse ...