Search
Now showing items 1-10 of 33
Regulation of Lateral Mobility of Amyloid Precursor Protein by an Alzheimer’s Disease Risk Gene: Picalm
Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ...
Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ...
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around
the recording electrode that contributes to the electrical activity recorded by the electrode. More
specifically, ...
Evaluation of Early Pathogenic Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
(2017-12-07)
Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder in the elderly, characterized by severe loss of memory and higher cognitive functions. In the hundred years since its discovery, Alzheimer’s ...
Dynamics of Invariant Object Representations in the Monkey Inferotemporal Cortex
(2018-06-18)
Vision is computationally challenging because objects in the real world can change in size, position, viewpoint etc., and therefore cast a myriad images on the retina. Viewpoint changes are particularly challenging because ...
The Role of Cytoskeletal Morphology in the Nanoorganization of Synapse
(2018-01-10)
Synapse is the fundamental unit of synaptic transmission. Learning, memory and neurodegenerative diseases of the brain are attributed to the maintenance and alteration in synaptic connections. The efficiency for synaptic ...
Mechanisms of Dopaminergic Neurodegeneration in Parkinson's Disease
(2018-07-18)
Parkinson’s disease (PD) is a debilitating movement disorder. The cardinal symptoms of PD are bradykinesia, resting tremors and rigidity. PD is characterized by degeneration of dopaminergic neurons of A9 region, substantia ...
Factors Regulating Cerebellar Granule Neuron Progenitor Proliferation
Cerebella granule neuron progenitors (CGNPs) give rise to a homogenous group of neurons called the cerebellar granule neurons in the developing cerebellum (a hindbrain structure classically associated with fine motor ...
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ...
Is Spatial Map Shaped by Environmental Determinants?
Humans and other animals form internal mental maps of the outer world in order to navigate. Hippocampal place cells and grid cells in MEC (medial entorhinal cortex) are the key components of this navigation system. However, ...