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Investigating mechanisms underlying astrocytic involvement in depressive-like behavior and antidepressant action
Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ...
Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ...
Astroglial development as the basis for the effects of early life stress on adult depressive-like behavior
This thesis investigates the enduring effects of early-life stress, specifically maternal separation, on astroglial population and the subsequent behavioral outcomes in adult mice. While the persistent impact of early-life ...