Browsing Centre for Neuroscience (CNS) by Title
Now showing items 1-20 of 37
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Astrocytes regulate oligodendrocyte development and myelination in the mammalian brain
Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ... -
Astroglial development as the basis for the effects of early life stress on adult depressive-like behavior
This thesis investigates the enduring effects of early-life stress, specifically maternal separation, on astroglial population and the subsequent behavioral outcomes in adult mice. While the persistent impact of early-life ... -
Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ... -
Behavioral and Neural bases of Subcomponents of the Attentional Blink
Attention enables us to select relevant stimuli for enhanced sensory processing and decision-making. Yet, our ability to pay attention is severely capacity limited. This limitation is clearly revealed when we seek to perform ... -
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ... -
Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ... -
Computational mechanisms underlying eye-head coordination
Gaze or eye-head coordination is an ethologically and physiologically important process that directs the visual system to objects of interest. Due to its relative simplicity, it is an ideal system to study multi-effector ... -
Computational Mechanisms Underlying the Voluntary Control of Reach Movement Planning and Execution
In everyday life we make a variety of reaching movements. Most of these reaching movements have a clear objective of bringing the hand to the spatial location of the object of interest. Although we typically do not explicitly ... -
Decoding of Attention and Behavioral State Using Local Field Potentials
Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ... -
Differential Regulation of Calcium Dependent Phase Separation and Modular Assembly of Sap97/Hdlg Enriched Molecular Complexes
Recent studies over a few decades have changed the perspective of the molecular architecture of functional zones within synapses and other cell junctions. Observations in the last decade confirm Post Synaptic Density as ... -
Dynamics of Invariant Object Representations in the Monkey Inferotemporal Cortex
(2018-06-18)Vision is computationally challenging because objects in the real world can change in size, position, viewpoint etc., and therefore cast a myriad images on the retina. Viewpoint changes are particularly challenging because ... -
Effect of Stimulus Normalization and Visual Attention at multiple scales of Neural Integration
The effect of visual attention on neural signals has been extensively studied using various techniques such as macaque neurophysiology and human electro/magneto encephalogram (EEG/MEG). Depending on the technique, different ... -
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around the recording electrode that contributes to the electrical activity recorded by the electrode. More specifically, ... -
Evaluation of Early Pathogenic Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
(2017-12-07)Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder in the elderly, characterized by severe loss of memory and higher cognitive functions. In the hundred years since its discovery, Alzheimer’s ... -
Factors Regulating Cerebellar Granule Neuron Progenitor Proliferation
Cerebella granule neuron progenitors (CGNPs) give rise to a homogenous group of neurons called the cerebellar granule neurons in the developing cerebellum (a hindbrain structure classically associated with fine motor ... -
How does familiarity change visual object representations ?
Familiarity with something implies having a close acquaintance with that item, generally acquired over a period of time. Apart from single items, we have experienced getting familiar with a pair of items (like a mouse and ... -
Investigating mechanisms underlying astrocytic involvement in depressive-like behavior and antidepressant action
Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ... -
Investigating the neural basis of spatial attentional components with probabilistic and reward cueing
We are constantly inundated with an abundance of sensory information. “Attention” enables the selection of relevant information and filtering out irrelevant information, to guide adaptive behavior. While attention can be ... -
Is Spatial Map Shaped by Environmental Determinants?
Humans and other animals form internal mental maps of the outer world in order to navigate. Hippocampal place cells and grid cells in MEC (medial entorhinal cortex) are the key components of this navigation system. However, ... -
Maternal Immune Activation Perturbs Gene Expression in the Embryonic Brain Leading to Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) constitutes a spectrum of developmental disorders that share common phenotypes of social and communication deficits and repetitive behaviours. ASDs have many possible underlying causes ...