Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease

Abstract

The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the function of a variety of target proteins, at a very early stage. Taken together, these results contribute to the existing knowledge regarding the molecular mechanisms leading to the onset and progression of AD. Since the lack of complete understanding of the disease process underlies the failure in developing effective disease-modifying therapies against AD, it is hoped that the findings from this study will contribute to a better understanding of AD pathology and help in the identification of therapeutic targets