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    Browsing Biochemistry (BC) by Title

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      • Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis. 

        Singh, Satpal
        Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...
      • Uncovering the Role of Mitochondrial Co-chaperones and Artificial Antioxidants in Cellular Redox Homeostasis 

        Srivastava, Shubhi (2018-02-14)
        The role of mitochondria is multidimensional and ranges in vast areas, including apoptosis, cellular response towards stress, metabolism, which is regulated by a plethora of proteins, acting together to maintain cellular ...
      • Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease 

        Saha, Prasenjit Prasad (2018-09-04)
        Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in ...
      • Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter 

        Namala, Gayatri Devi M
        The mitochondrion is a double membrane-bound organelle found in all eukaryotic organisms. Mitochondria are endosymbiotic, autogenous organelles referred to as “Powerhouse” of cells due to their ability to synthesize ATP ...
      • Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases 

        Roy, Nainita (2013-04-04)
        Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ...
      • Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression 

        Samaddar, Madhuja (2018-01-28)
        Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ...
      • Understanding mRNA fate regulation by RGG motif protein, Sbp1 

        Bhatter, Nupur
        Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ...
      • Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation 

        Ghosh, Dipayan
        This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ...
      • Understanding the adaptive responses of Salmonella Typhimurium during bile stress 

        Singh, Madhulika
        Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ...
      • Understanding the anticancer potential of inhibitor of BCL2, Disarib in Oral Cancer Cells and its Toxicological Evaluation in Rodents 

        Siddiqua, Humaira
        Overexpression of BCL2 has been reported in several cancers, such as B-cell lymphomas, leukemias, colorectal adenocarcinoma, breast cancer, prostate cancer, and oral cancer, making it an excellent target for cancer treatment. ...
      • Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression 

        Waingankar, Tejashree Pradip
        The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...
      • Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens 

        Chatterjee, Sharanya
        Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ...
      • Understanding the Dynamic Organization of the Presequence-Translocase in Translocation of Preproteins Across Mitochondrial Inner Membrane 

        Pareek, Gautam (2018-05-08)
        Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ...
      • Understanding the Heat Shock Response Pathway in Plasmodium Falciparum and Identification of a Novel Exported Heat Shock Protein 

        Grover, Manish (2018-02-27)
        Infections or diseases are not just stressful for the one who encounters it. The pathogens causing the same also have to deal with the hostile environment present in the host. The maintenance of physiological homeostatic ...
      • Understanding the Long-term Impact and Mechanism of Action of Endosulfan, an Organochlorine Pesticide on Fertility, Development and Growth of Mice 

        Sharma, Anju
        Endosulfan (ES) is one of the major broad-spectrum organochlorine pesticides categorized as Class II (moderately hazardous) by WHO and Class I (highly acutely toxic) by US Environment Protection Agency. Although the use ...
      • Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria 

        Dahal, Sumedha
        Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ...
      • Understanding the Mechanism of Homologous Recombination in Mycobacterium Tuberculosis : Exploring RecA as an Antibacterial Target and Characterization of Holliday Junction Resolvases 

        Nautiyal, Astha (2018-08-09)
        Homologous recombination (HR) is conserved across all three domains of life and is associated with a number of key biological processes. Over the years, numerous genetic, biochemical and structural studies have uncovered ...
      • Understanding the Mechanism of Noncanonical Functions of RAGs in Lymphoid Cancer and Glioblastoma 

        Paranjape, Amita M
        Recombination activating genes (RAGs) composed of RAG1 and RAG2, are the endonuclease involved in V(D)J recombination, which is critical for adaptive immunity in mammals. Activation-induced cytidine deaminase (AID), expressed ...
      • Understanding the Regulation of mRNA Translation Repression by RGG-motif Proteins 

        Poornima, G
        Messenger RNA translation is one of the most energy expensive steps in the process of gene expression and therefore translation regulation is critical for maintaining cellular homeostasis. In contrast to transcriptional ...
      • Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis 

        Birje, Abhijit
        Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...

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