Asymmetric Synthesis of Amino Acid Derivatives and Total Synthesis of Biologically Active Natural Products

Abstract

The thesis describes the development of synthetic method for the synthesis of -amino acid esters, amides, thioesters using Ellman sulfinimines. The procedure developed was further utilized in the synthesis of di and tri peptides without racemization. Further, the use of chiral pool tartaric acid and chiral furyl carbinols in the total synthesis of natural products is described. The targeted natural products include D-lyxo and xylo -Phytospingosines, sphingofungin B, AKML-B, ()-(6S,9R,10R)- Bovidic acid, Towards the synthesis of schulzeine B, and Phomopsolidones.