Division of Chemical Sciences
Recent Submissions
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Isoform Specific Synthetic Glutathione Peroxidase Mimetics in Redox Regulation of Cell Death and Diseases
Reactive oxygen species (ROS)-induced oxidative stress has been implicated in various pathologies and cell death processes. Cells have antioxidant systems to neutralize the harmful effects of excess ROS. Glutathione ... -
Excited State Intramolecular Charge Transfer: Ultrafast Electronic and Vibrational Spectroscopic Study
This thesis incorporates the understanding of the ultrafast excited state photoinduced intramolecular charge transfer (ICT) process in liquid phase. The molecular systems are studied by employing Ultrafast Raman Loss ... -
Engineering of Nanomaterials: Application in Antibacterial Activity, Bio-Analyte Detection and Environmental Remediation
Infectious diseases caused by pathogenic bacteria are creating a global health problem. In the recent report of World Health Organization (WHO), it has been mentioned that around 7 lacks people are dying each year worldwide ... -
Development and Applications of Portable Raman Spectroscopy Combined with Artificial Intelligence for Biomedicine
Currently, the global spectroscopic community is investigating the suitability of vibrational spectroscopy methods for point-of-care testing, histopathology, and rapid in-vivo biomedical diagnostics. Although Raman ... -
Identifying Bacterial Species, Detecting Antibiotic Resistance and Susceptibilities in Clinical Samples Using Raman Spectroscopy
Over the past few decades, Raman spectroscopy has found enormous applications in biology and medicine. Raman micro-spectroscopy is highly sensitive to the structure and composition of molecules and their surrounding moieties ... -
Investigation of strongly correlated paramagnetic state at sub-Kelvin regime for S ≥ 1/2 systems: Role of disorder and dimensionality
A magnetic system usually orders ferro- or anti-ferromagnetically at temperatures comparable to interaction strength between the spins. Moreover, an interacting spin system tends to order with the increase of dimensionality ... -
Computational Modeling of two Dimensional Heterostructures for Optoelectronic and Catalytic Applications
Two-dimensional van der Waals (2D-vdW) materials have attracted significant attention for their unique and excellent properties. The properties of the 2D-vdW materials can be precisely engineered using various techniques ... -
Accelerated Search of Catalysts Using Density Functional Theory and Machine Learning
The need for clean and renewable energy resources has propelled the interest in designing new catalysts producing energy from renewable resources and alternate cleaner fuels such as hydrogen, methane, ammonia, ethylene, ... -
Construction of C-C Bonds by Photocatalysis via Radical Addition Cascade Cyclization (RACC): Synthesis of Heteroatom-Containing Small Molecules
The thesis presents photocatalytic methods for synthesizing small organic molecules at room temperature. The thesis is divided into four sections. Section A presents the general introduction to the thesis. Section B is ... -
HBS Constrained Antiparallel β-Sheets and Flat Toroid Turns; Homoserine, Thioamide and 1,3-Thiazine Containing Peptidomimetics: Design, Synthesis, Conformational Analyses and applications
In chemical biology, short peptidomimetic biological active models have been widely used for anti-microbial activity, drug development, catalysis, and amyloidogenesis. In this thesis, I have synthesized several unnaturally ... -
B, N containing π- conjugated systems: room temperature phosphorescence, fullerene complexation, and cell differentiation
Advances in heteroatom (B, N, and B-N) incorporated π-conjugated systems have attracted considerable attention because of their desirable properties and widespread applications. Substitution of isoelectronic B–N units for ... -
Electronic, Magnetic and Local structure of Some Selected Strongly Correlated Systems
According to independent electron band structure theories, transition metal oxides (TMOs) with partially filled 3d valence band are predicted to be metallic in nature. Though in reality, most of them are insulators. Mott ... -
Enantioselective Annulation Reactions: From Fischer Indolization to de novo Arene Construction
In summary, we have developed the first decarboxylative [4+2]-annulation of ethynyl benzoxazinanones with azlactones for the enantioselective synthesis of cyclic α-quaternary α-acylaminoamides.25 This direct and modular ... -
Electron Microscopy Investigations on Solution Grown Stannous Oxide Nanosheets
In this thesis, motivated by the possibility of studying rich scientific phenomena using morphology controlled single crystals, experimental observation of new features in the growth and structure of layered oxide materials ... -
Metal Ion Mediated Riboswitch Folding and Cognate Ligand Sensing
Riboswitches are noncoding RNA molecules that can control gene expression upon cognate ligand binding. Riboswitches are primarily present in bacteria and are crucial for bacteria's survival, which makes riboswitches ... -
Developing a tunable, adaptive plasmid selection system to screen Aminoacyl-tRNA synthetase variants
The genetic code refers to a set of rules used by living organisms to translate information encoded within the genetic material (DNA/mRNA sequences) into proteins. All organisms generally encode 22 proteinogenic or canonical ... -
Employing Arynes in Unique Multicomponent Reactions and a Strain-Release Ene Reaction
Arynes are highly reactive electrophilic intermediates, extensively used for synthesizing various benzo-fused heterocycles and 1,2-disubstituted benzenes. Among the numerous reactions of arynes, multicomponent coupling ... -
2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the ... -
Structural and Electrochemical Investigation of Bisulfate and Hydroxysulfate based Polyanionic Cathodes
The discovery of LiFePO4 cathode for Li-ion battery ushered intensive study on polyanionic high-voltage battery insertion materials. Polyanionic materials offer rich crystal chemistry, robust framework, voltage tunability, ... -
Electrochemical Behavior of Mn-based Oxide Cathode Materials for Alkali-ion Batteries: Study of Cationic and Anionic Redox Reactions
Better batteries are being developed in response to the growing demand for clean energy in order to replace conventional fossil fuels with renewable energy for affordable and long-term energy storage. Lithium-ion ...
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