Organic Chemistry (OC)
Recent Submissions
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Total synthesis of the macrolactone core of migrastatin, formal synthesis of (+)-ratjadone A, and towards the synthesis of sphingofungin F
The thesis entitled “Total synthesis of the macrolactone core of migrastatin, formal synthesis of (+)-ratjadone and Towards the total synthesis ofsphingofungin F” is divided into three chapters and an appendix highlighting ... -
Synthesis and Functionalization of Carbon and Sulfur-based Nanomaterials: Physical Properties and Molecular Recognition
In recent years carbon-based nanomaterials are growing rapidly in the field of science and technology, due to the tunable optical and physical properties such as electronic arrangement, photostability, flexibility and ... -
Sulfoximine and Sulfoxonium Ylide Directed C-H Activation and Domino Cyclization: Construction of Heterocyclic and Carbocyclic Rings
The thesis presents the construction of heterocyclic and carbocyclic rings using rhodium-catalyzed C-H bond activation followed by a tandem cyclization strategy. This involves the synthesis of heterocyclic compounds such ... -
Ru (II)-Catalyzed C−H Activation: Amide-Directed 1,4-Addition of Ortho C−H Bond to Maleimides
Transition metal catalyzed functionalization of C-H bond to C-C bond is advantageous and atom economical. The use of directing groups is intended to overcome the challenges associated with the C-H activation such as low ... -
Engaging Small Organic Molecules and Self-Assemblies for ‘Label-Free’ Recognition of Biologically Relevant Analytes
The thesis entitled ‘Engaging Small Organic Molecules and Self-Assemblies for ‘Label-Free’ Recognition of Biologically Relevant Analytes’ mainly deals with design and synthesis of various types of small molecular probes ... -
New Anthraquinone & Xanthone based Ligands as Potential Anti Cancer Agents via Selective Stabilization of G Quadruplex DNA and Theoretical Insights into G Quadruplex RNA Binding with Certain Small Molecules
In recent years, different small molecules have been synthesized for selective stabilization of G-quadruplex DNA structures over the most abundant double-stranded duplex DNA. Stabilization of G-quadruplex DNA by small ... -
Catalytic Asymmetric Direct and Vinylogous Aldol, Michael and Alkylation Reactions
Pyrazoles and pyrazolones are a highly explored and privileged class of aza-heterocycles with a wide range of applications, thereby rendering a recurring interest in their synthesis and functionalization. Majority of the ... -
Design, Synthesis and Conformational Analysis of Hydrogen Bond Surrogate (HBS) Stabilized Helices in Natural Sequences. Helically Constrained Peptides for Potential DNA-Binding
Thesis titled, “Design, Synthesis and Conformational Analysis of Hydrogen Bond Surrogate (HBS) Stabilized Helices in Natural Sequences. Helically Constrained Peptides for Potential DNA-Binding”, describes the development ... -
Synthetic Applications of C-2 Substituted Glucal
This report concerns the development of a synthetic approach towards synthesis of seven-membered septanosides, such as, substituted oxepanes from protected 2-hydroxyglycals. Important precursors to the synthesis of the ... -
Stereocontrol through Catalytic Enantioselective C(sp2)−H and C(sp3)−H Alkylation: From Bifunctional Organocatalysis to Iridium-Catalysis
This thesis, entitled “Stereocontrol through Catalytic Enantioselective C(sp2)−H and C(sp3)−H Alkylation: From Bifunctional Organocatalysis to Iridium-Catalysis” primarily deals with the development of various catalytic ... -
Achieving Efficiency and Specificity in Multifarious Systems for Anti-cancer Gene Therapeutics
The research work described in this thesis encompasses the syntheses, characterization and bioactivity determination of various novel systems crafted for achieving high efficacy and targeted gene therapeutic effect in ... -
Nucleophilic Addition reactions of 2-Aza-allyl anion: Application to the Total Synthesis of Natural Products
The thesis entitled “Nucleophilic Addition reactions of 2-Aza-allyl anion: Application to the Total Synthesis of Natural Products’’ is divided into two sections with an appendix. First section of the thesis details the ... -
Development of Stimuli-Responsive Self-Assembled Materials for Biomolecular Applications
The thesis entitled ‘‘Development of Stimuli-Responsive Self-Assembled Materials for Biomolecular Applications’’ deals with the design, synthesis, and characterisation of low molecular weight hydrogel systems as well as ... -
Design and Synthesis of Stimuli-responsive Gelators and Novel Gemini Surfactants and Characterization of their Properties upon Self-assembly
Chapter 1. A Brief Overview of Gemini Surfactants and Low Molecular-Weight Gelators (LMWGs) The first part of this chapter gives a brief account of the research done in the area of aqueous 3D-(ca. micelles and vesicles ... -
Bile Salts in Supramolecular Chemistry: Synthesis of Fluorescent Nanoclusters, Oxide Nanoflowers, and Anion Effect on Metallogels
In summary, we have explored an interesting pH-dependent sensitization of Tb(III) using methyl salicylate (MS) as a sensitizer in aqueous media. Methyl salicylate was found to be a specific sensitizer for Tb(III) but not ... -
Regioselective C-H Amidation Reactions using Directing Group Strategy and its Application in Organic Synthesis
The thesis represents an approach for the C-H bond activation using directing group strategy. The C-H activation happens through five/six-membered metallacycle through concerted metallation deprotonation. Further ... -
Properties and Applications of Metal Cholate Hydrogels
This thesis presents a detailed study on the unusual properties of silver cholate, applications of lanthanide cholate gels, enhanced luminescence of lanthanides by water, and the mechanism of formation of these gels. ... -
A Mitsunobu-Michael Reaction Sequence to N-Heterocyclic Variants and Ti(III)-Mediated Synthesis of Terpenoids and N-Fused Indoles
The research work delineates a flexible and novel route for the diastereoselective construction of diversely substituted N-heterocyclic variants as valuable scaffolds for natural products and pharmaceuticals, starting from ... -
Total Synthesis of Natural Products Diospongin a, Cryptofolione, CryptopyranmoscatoneB2, SCH725674 and Towards the Total Synthesis of Palmerolide C
First chapter of the thesis describes the total synthesis of tetrahydropyran containing natural products, diospongin A, cryptopyranmoscatone B2, hydroxy δ-lactone containing natural product cryptofolione and macrolactone ...
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