Organic Chemistry (OC)
Recent Submissions
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Functionalized Nanomaterial and Metallocycle for Selective Antibacterial, Diagnosis, and Anti-cancer Activity
The evolution of drug resistant bacteria has become a severe threat to public health globally. The misuse of conventional antibiotics has led to the development of multi-drug resistant bacteria. Even though antibiotics ... -
N-Heterocyclic Carbene-Catalyzed Synthesis of Oxazolones, e-Lactones and N-N Axially Chiral Molecules
The diverse reactivity of N-heterocyclic carbenes (NHCs) in organocatalysis is due to the possibility of different modes of action. Although NHC-bound enolates and dienolates were well-known, the NHC-bound cross-conjugated ... -
Engineering of Nanomaterials: Application in Antibacterial Activity, Bio-Analyte Detection and Environmental Remediation
Infectious diseases caused by pathogenic bacteria are creating a global health problem. In the recent report of World Health Organization (WHO), it has been mentioned that around 7 lacks people are dying each year worldwide ... -
Construction of C-C Bonds by Photocatalysis via Radical Addition Cascade Cyclization (RACC): Synthesis of Heteroatom-Containing Small Molecules
The thesis presents photocatalytic methods for synthesizing small organic molecules at room temperature. The thesis is divided into four sections. Section A presents the general introduction to the thesis. Section B is ... -
HBS Constrained Antiparallel β-Sheets and Flat Toroid Turns; Homoserine, Thioamide and 1,3-Thiazine Containing Peptidomimetics: Design, Synthesis, Conformational Analyses and applications
In chemical biology, short peptidomimetic biological active models have been widely used for anti-microbial activity, drug development, catalysis, and amyloidogenesis. In this thesis, I have synthesized several unnaturally ... -
Enantioselective Annulation Reactions: From Fischer Indolization to de novo Arene Construction
In summary, we have developed the first decarboxylative [4+2]-annulation of ethynyl benzoxazinanones with azlactones for the enantioselective synthesis of cyclic α-quaternary α-acylaminoamides.25 This direct and modular ... -
Employing Arynes in Unique Multicomponent Reactions and a Strain-Release Ene Reaction
Arynes are highly reactive electrophilic intermediates, extensively used for synthesizing various benzo-fused heterocycles and 1,2-disubstituted benzenes. Among the numerous reactions of arynes, multicomponent coupling ... -
2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the ... -
Synthesis and Studies of Covalent Polydiacetylene Glycopolymers as Scaffolds to Uncover Intricate Carbohydrate-Protein Interactions
Overall, the Thesis work establishes: • Monomeric and multimeric ligand-lectin interactions occurring at cell surfaces that could be assessed using purified protein and cellular model system, namely, glycovesicles; • ... -
Radical and Lewis Acid Mediated Syntheses of Panaginsene, Indole-Fused Azabicyclo[3.3.1]Nonane and Davanoids
The thesis contains radical and Lewis acid-mediated syntheses of panaginsene, indole-fused azabicyclo[3.3.1]nonanes, and davanoids. The thesis includes three chapters; chapter-I contains the total synthesis of panaginsene, ... -
Diverse Applications of Luminescent Metallocholate Hydrogels
Supramolecular gels are soft materials consisting of a solid three-dimensional network with noncovalent interactions such as hydrophobic interactions, hydrogen bonding, cation-п, and п- п interactions. Due to their soft, ... -
Total Synthesis of Piperidine and Pyrrolidine Alkaloids and Towards the Total Synthesis of Strychnine
Total synthesis of natural products is an important area of contemporary interest in synthetic organic chemistry. Total synthesis of natural products serves as a platform for the development of new synthetic strategies ... -
C-H Bond Functionalization and Tandem Cyclization with Alkynoates and Maleimides Using Directing Group Strategy
The thesis presents manganese‒ and rhodium‒catalyzed C‒H bond activation and tandem cyclization reactions. These reactions lead to the construction of carbon‒carbon bonds using directing group strategy. The thesis is divided ... -
Extending Aryne Chemistry: Application to Insertion Reactions, Multicomponent Couplings, Molecular Rearrangements and Arylation Reactions
Arynes are highly reactive electrophilic intermediates, which can be utilized in various carbon-carbon bond-forming reactions including pericyclic reactions, insertion reactions, multicomponent couplings (MCCs), molecular ... -
Allylic Halogenation Route to Latent-Active Trans-Glycosylation of Allyl Glycoside Donors
Allylic halogenation of allyl glycosides as a new route to allyl glycoside donors in glycosylations is investigated in this thesis. Allyl functionality is one of the commonly adopted protecting groups to hydroxyl groups ... -
N-Heterocyclic Carbene (NHC)-Catalyzed Stereoselective Synthesis of Six-Membered Heterocycles and Carbocycles
N-Heterocyclic carbene (NHC) based catalysis is employed for the generation of α,β-unsaturated acylazoliums followed by their interception with various nucleophiles, the formal [3+3] annulation reactions for the construction ... -
Analytical Applications of Bile Acid-derived Soft Materials
Supramolecular gels are soft materials with solid-like properties such as supporting weight and retaining shape; and some liquid-like features which make them injectable, printable, etc. On the other hand, lanthanide-based ... -
Construction of Carbon-Heteroatom and Heteroatom-Heteroatom bonds using Iodine and Zinc catalysts
The thesis entitled “Construction of Carbon-Heteroatom and Heteroatom-Heteroatom bonds using Iodine and Zinc catalysts” has been divided into five chapters. Chapter 1 describes a general introduction to iodine, hyper-valent ... -
Stereoselective synthesis of functionalized allenes, total synthesis of monticolides A and B, and towards the total synthesis of tulearin C
The thesis, entitled as “Stereoselective synthesis of functionalized allenes, Total synthesis of Monticolides A and B, and towards the total synthesis of Tulearin C” is divided into two chapters. Section A chapter-1 deals ... -
Design and Synthesis of New Delivery Vehicles for Anti- Cancer Therapeutics
The thesis entitled ‘‘Design and Synthesis of New Delivery Vehicles for Anti-Cancer Therapeutics’’ encloses the syntheses, characterization and bioactivity determination of the novel systems designed for achieving high ...