Search
Now showing items 1-10 of 37
Establishment of human ectopic liver tissue in immunocompromised mice as a model for Hepatitis C Virus studies
Infection with hepatitis C virus (HCV) leads to an inflammatory condition which may progress to liver cirrhosis and in some cases, hepato-cellular carcinoma. Though, new drugs are being added to the list of HCV therapeutics, ...
Studies on the post-transcriptional regulation of genes of glutamate utilization pathway in Pichia pastoris and a role for Retrograde regulation protein 1
The methylotrophic yeast, Pichia pastoris can utilize compounds such as glucose, glycerol, methanol, acetate, amino acids, or oleic acid as the sole source of carbon. However, the regulation of synthesis of key enzymes of ...
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...
New insights into the role of condensin in Saccharomyces cerevisiae
Structural Maintenance of Chromosomes (SMC) complexes are highly conserved from prokaryotes to eukaryotes. Saccharomyces cerevisiae has six SMC proteins which form three SMC-complexes in association with non-SMC subunits ...
Regulation of RecA nucleoprotein filament stability by RecX and the effects of RecA-membrane interaction on the activities of RecA in mycobacteria
E. coli RecA is a multifunctional protein known to be associated with the cell membrane, forming foci often located at the cell poles, which gets redistributed along the length of the cell during SOS response. Several lines ...
Functional characterization of Salmonella Typhimurium encoded Cold Shock Protein E during stress responses, biofilm formation and virulence
Overall, this study reports novel functional roles of S. Typhimurium encoded CspE during bile resistance, biofilm formation and in vivo virulence. It also establishes importance of an uncharacterised protein YciF, implicating ...
Identification and Biochemical Characterization of Novel Inhibitors of Nonhomologous End Joining: Implications in DNA Double-Strand Break Repair and Cancer Therapy
To summarize, in the present study, we have synthesized and characterized three novel NHEJ inhibitors targeting DNA Ligase IV, with several fold better efficacy compared to SCR7 and thus potential to be developed as cancer ...
Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin
Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ...
Mechanistic Insights Into Heat Shock Protein 90 (Hsp90) Trans-splicing in Giardia lamblia
Hsp90 gene is conserved and encoded by a single ORF with none to many cis-spliced introns across the biological kingdom. Previous studies from our lab have shown that Hsp90 gene in Giardia lamblia has a split nature having ...
Kinetic, Catalytic and Epigenetic Properties of HpyAXVII DNA Methyltransferase – a Phasevarion in the Human Pathogen Helicobacter pylori
Helicobacter pylori is the leading cause of gastric cancer in human beings. It is a helix-shaped, Gram-negative, motile bacteria that colonizes the gastric mucosa and eventually the gastric epithelium. It has an overabundance ...