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HBS Constrained Antiparallel β-Sheets and Flat Toroid Turns; Homoserine, Thioamide and 1,3-Thiazine Containing Peptidomimetics: Design, Synthesis, Conformational Analyses and applications
In chemical biology, short peptidomimetic biological active models have been widely used for anti-microbial activity, drug development, catalysis, and amyloidogenesis. In this thesis, I have synthesized several unnaturally ...
Construction of C-C Bonds by Photocatalysis via Radical Addition Cascade Cyclization (RACC): Synthesis of Heteroatom-Containing Small Molecules
The thesis presents photocatalytic methods for synthesizing small organic molecules at room temperature. The thesis is divided into four sections. Section A presents the general introduction to the thesis. Section B is ...
Synthesis and Studies of Covalent Polydiacetylene Glycopolymers as Scaffolds to Uncover Intricate Carbohydrate-Protein Interactions
Overall, the Thesis work establishes:
• Monomeric and multimeric ligand-lectin interactions occurring at cell surfaces that could be assessed using purified protein and cellular model system, namely, glycovesicles;
• ...
2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The
applications are diverse in biological systems and organic synthesis. In the first part of the
thesis, 2,3-unsaturated sugars are used for the ...
Employing Arynes in Unique Multicomponent Reactions and a Strain-Release Ene Reaction
Arynes are highly reactive electrophilic intermediates, extensively used for synthesizing various benzo-fused heterocycles and 1,2-disubstituted benzenes. Among the numerous reactions of arynes, multicomponent coupling ...