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Structural and related studies on Mycobacterium tuberculosis pantothenate kinase
Pantothenate kinase (PanK) is a ubiquitous and essential enzyme that catalyses the first step in the universal Coenzyme A (CoA) biosynthetic pathway. In this step pantothenate is converted to phosphopantothentate, which ...
Structural and functional studies on DNA damage inducible protein 1 (Ddi1) from protozoa
Structural and functional investigations on DNA-damage inducible protein1 (Ddi1) from Entamoeba histolytica, Trypanosoma cruzi and Toxoplasma gondii have been carried out. Ddi1 belongs to the ubiquitin receptor family of ...
Structural and mechanistic studies on Staphylococcal RNA degrading enzymes and multienzyme complexes
RNA degrading enzymes and multi-enzyme complexes govern a variety of cellular
processes. The role of these enzymes and multi-enzyme assemblies has been suggested to govern
gene expression levels in bacteria with modulations ...
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid
mosaic model. Simulations and experimental studies have observed non-random mixing of
lipids and proteins in the membrane. In this ...
Functional and structural studies of proteins involved in telomere maintenance
The linear ends of the eukaryotic chromosomes are protected by a specialized nucleoprotein complex known as telomere. Telomeres consist of telomere DNA and telomere DNA binding proteins (known as shelterin complex). The ...
Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus
A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ...
Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin
Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes
acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for
influenza viral infection ...
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors
such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial
and temporal ...
Integration of sequences, structures, dynamics to study functional divergence in homologous proteins and their assemblies
Functions of proteins are governed by their sequences, structures, dynamics and assembly. Modulation of these factors during evolution renders functional divergence in related proteins that have originated from the common ...
Stereochemical studies on peptide and protein structures: Implications for validation, flexibility, and dynamics
Accuracy of 3-D structures of proteins is crucial, both in terms of its agreement with the experimental data used to determine the structure and stereochemistry, especially when they are utilized for applications like drug ...