Microbiology and Cell Biology (MCB): Recent submissions
Now showing items 81-100 of 250
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Response of Mycobacterium tuberculosis to Hypoxia and its physiological Significance - A Morphological and Molecular Level Study
Mycobacterium tuberculosis (Mtb) has evolved as an important clinical pathogen due to its ability to gain multidrug resistance, to enter into latency to persist there and to get reactivated from the latent infection in ... -
An integrative analysis of Cell Adhesion Molecules (CAMs) in Glioma: The Essential role of PTGFRN and ASTN1 in Glioma and Glioma Stem-like Cells
The central nervous system tissue contains neural stem cells which differentiate and give rise to the neurons and glial cells. The glial cells maintain neurons by providing nutrients, physical support and protection. Unlike ... -
Transcriptional Regulation of Fatty Acid Transport by Sirtuin 2
The heart is a highly dynamic organ and under normal physiological conditions, it is heavily dependent on fatty acid oxidation to meet its energy requirements (Abumrad and Goldberg 2016). Fatty acid transport is a crucial ... -
Mechanistic and Functional Insights into Mycobacterium bovis BCG Triggered PRR Signaling : Implications for Immune Subversion Strategies
Pathogenic mycobacteria are among the most dreadful pathogens known to mankind as one third of the world’s population is latently infected with M. tuberculosis, the causative agent of pulmonary tuberculosis. Host immune ... -
Nucleoid-associated Proteins of Mycobacterium tuberculosis : Insights into their Functions
Bacteria face the challenging task of compacting their chromosomes to accommodate them in a small cytoplasmic volume and at the same time maintaining the nucleoids in a highly organized and dynamic state for transcription, ... -
Role of SIRT6 in the regulation of mTOR signalling and global protein synthesis
Cells are constantly engaged in the process of making and breaking proteins in a highly organized manner. However, protein synthesis is an energetically expensive process and often competes with other cellular repair and ... -
ROLE OF SIRT6 AND PARP-1 IN MUSCLE HOMEOSTASIS
Sirtuins and PARPs are stress responsive family of proteins regulating genome instability, inflammation, aging-related diseases and energy metabolism. Both sirtuins and PARPs are NAD+ enzymes with deacetylase and ADP-ribose ... -
Malat1 and COP1 mediated host responses orchestrate mycobacterial pathogenesis
Tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), is viewed to be the predominant cause of death arising due to bacterial infection. Further, the emergence of MDR/XDR strains and co-infections has compounded ... -
Studies on the regulatory roles for Retinoic Acid (RA) during host-microbial interaction : implications for S. aureus and C. albicans infections
Chronic inflammatory disorder is one of the leading causes of death worldwide. Association between pathogenic infection and inflammation governs tissue homeostasis, which relies on extensive crosstalk among signaling ... -
Initiation of protein synthesis : Role of the three consecutive GC base pairs in the anticodon stem of initiator tRNAs
The presence of the three consecutive GC base pairs in the anticodon stems of the initiator tRNAs (3GC base pairs) are a highly conserved and a vital feature of the initiator tRNAs in all the domains of life. How this ... -
Topoisomerase i from mycobacterium tuberculosis : Dynamics of enzyme function and inhibitor development
Inside the bacterial cell, the genetic material is maintained in a negatively supercoiled state within a compact space. The supercoiling of the genome undergoes topological perturbations during a variety of cellular processes ... -
Probing the Splicing and Enzymatic Function of Fission Yeast Prp16 – A DEAD Box RNA Helicase
Nuclear pre-mRNA splicing occurs at precisely conserved sequence elements at and around the splice sites which result in ligation of exons and release of intron as lariat. The Schizosaccharomyces pombe genome is an apt ... -
The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria
The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria Submitted by Atul Pradhan (S.R. No. 03-04-00-10-11-14-1-11678) Background Information: Mycobacteria maintain heterogeneity in ... -
Panoramic View of RNA Binding Proteins (RBPs) in Glioblastoma : IMP3, an RBP, is Essential for Glioma Stem-like Cell Maintenance
Gliomas are primary brain tumors in adults that are believed to originate from different types of glial cells. Central nervous system gliomas pose particularly difficult problems because of their tendency towards malignancy, ... -
Identification and Characterisation of a miRNA releasing activity from Caenorhabditis elegans
MicroRNAs (miRNA) are endogenous, small non coding RNAs, which play a prominent role in eukaryotic gene regulation. Perturbations leading to an altered abundance of miRNAs can lead to pathological conditions like neurological ... -
Understanding the redox homeostatic mechanisms in Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is an obligate intra-cellular pathogen that causes the disease tuberculosis (TB) in its human hosts. An estimated 1% of the world population is reported to get infected with the disease ... -
Immunological insights into Epidermal Growth Factor Receptor Signaling: Implications for host-pathogen interactions
Infectious diseases account for a large proportion of morbidity and mortality worldwide. The major global efforts lie in effectively enhancing the health span of infected individuals and more importantly, curbing infection ... -
Elucidating Deregulated Novel Pathways in Glioma through Genetic and Epigenetic Approaches
Malignancy of glial cells is termed as glioma. Gliomas comprise of thirty percent of all tumors of the central nervous system (CNS) and eighty percent of malignant brain tumors (Goodenberger and Jenkins, 2012). Astrocytoma, ... -
Physiological Role of Arr, an ADP-ribosyltransferase in Mycobacterium smegmatis
The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ... -
Regulation of Host Innate Immune Responses by Hippo Signaling Pathway during Pattern Recognition Receptors (PRRs) Driven Inflammation : Implication for Host-Pathogen Interactions
Innate immunity refers to the first line of defence system of the host that comes into play immediately or within hours of appearance of invading pathogens like bacteria, viruses and fungi. Cells of the innate immune system ...