Microbiology and Cell Biology (MCB): Recent submissions
Now showing items 61-80 of 250
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Functional characterization of a new enzymatic activity of the ‘miRNase’-XRN-2 from Caenorhabditis elegans.
Ribonucleic acid (RNA) molecules play a central role in every pivotal process in the cell, and ribonucleases (RNases) are critical for their biogenesis, processing, and degradation. Therefore, RNases are indispensable for ... -
PP2A-phosphatase and Polo-like kinase 1 regulates spindle positioning by orchestrating the cortical levels of the dynein adaptor NuMA
The mitotic spindle is a microtubule-based diamond shape structure that captures chromosomes and facilitates their segregation during anaphase. Proper positioning of the mitotic spindle is critical for defining the ... -
Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli
The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ... -
Interactions between host cellular factors and Rotaviral viroplasmic non-structural proteins NSP5, NSP2 and their influence on virus replication
Overall, the present study demonstrates the dynamic nature of rotavirus viroplasm and how it manipulates the intracellular environment by intracellular relocalization of host proteins and their sequestration in viroplasms ... -
The role of Rv1860 from M. tuberculosis in modulating the host immune response
Tuberculosis continues to prevail as the major cause of mortality from any single pathogen around the world, despite implementation of control programs and the availability of effective drugs and the vaccine BCG. Mycobacterium ... -
Role of SIRT6 in the Regulation of Glucose Metabolism and Fatty Acid Uptake in Heart
The adult heart heavily relies on fatty acid for most of its energy supplies. The heart derives most of the fatty acid from circulation. Hence, fatty acid uptake forms a crucial step in cardiac metabolism. Studies have ... -
Molecular basis of attenuation of the live attenuated Japanese encephalitis virus vaccine SA14-14-2
Japanese encephalitis virus is a member of Flaviviridae family. Flaviviridae family has four genera which comprises of Flavivirus, Pestivirus, Hepacivirus and Pegivirus. The global burden of disease caused by these viruses ... -
Investigating Partners of OsMADS1 Transcription Factor and functions for some associated factors for roles in rice inflorescence and floral development
Title: Investigating Partners of OsMADS1 Transcription Factor and functions for some associated factors for roles in rice inflorescence and floral development The classic ABCDE model for floral organ identity show that ... -
Studies on Rotavirus Nonstructural Protein 5 (NSP5)
Rotavirus is the most important agent of viral gastroenteritis in humans and animals and is responsible for about 600,000 deaths per annum. Most of these deaths occur in the developing countries and India is estimated to ... -
Elucidating the role of carbon metabolism genes chiA and yjiY in Salmonella pathogenesis.
Salmonella is a foodborne pathogen that causes debilitating enteric diseases in a wide range of hosts. While Salmonella Typhimurium causes self-limiting gastroenteritis in human beings, Salmonella Typhi causes typhoid fever ... -
Understanding the Significance of Ydcp, a Putative Peptidase Encoding Gene, in Virulence of Salmonella
Salmonella is a recognised enteric pathogen which infects several mammalian and avian hosts through faeco-oral route and establishes either a localised gastrointestinal inflammation and diarrhoea or a systemic fever, ... -
Investigating the redox signaling mechanisms during HIV-TB co-infection
Oxidative stress has been at the forefront of HIV/AIDS-related pathophysiologies since the early days of its discovery. Overcoming HIV-1 latency, wherein, the virus remains integrated in the host chromatin, undetected and ... -
Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis
Gliomas are the neoplasia of glial cells present in the brain and comprises of more than 70% of all the neoplasms of the central nervous system. They consist of a family of primary brain tumors that are categorized based ... -
Identifying key determinants underlying variable efficacy of BCG substrains against Pulmonary TB.
Protection conferred by BCG vaccine against adult pulmonary TB ranges from 0–80% based on large, well-controlled field trials. This variability is highly significant (P < 0.0001) and is regarded as being indicative of true ... -
The Molecular Basis for the Differential Antibiotic Susceptibility of Mycobacterial Subpopulations
Mycobacterial populations have evolved various strategies to withstand diverse stress conditions in the environment. One among these strategies is maintenance of phenotypic heterogeneity, in terms of cell morphology, ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Eukaryotic cellular pathways are maintained and coordinated through biomolecule turnover, which includes synthesis, trafficking, degradation of cellular components and their reutilization. The process of biomolecule ... -
Elucidating the mechanism of interaction of Salmonella with plants
Salmonella, is an established pathogen of members of the kingdom Animalia. Its principal species S. enterica serovars Typhi, Paratyphi and Typhimurium can cause various diseases ranging from typhoid fever to gastroenteritis ... -
Division of the Salmonella Containing Vacuole and Other Virulence Strategies Employed by Salmonella
Salmonella comprises a genus of rod-shaped, Gram-negative, non-sporulating and primarily motile enterobacteria. They have remained a major cause of morbidity and mortality worldwide, claiming several hundreds of lives per ... -
Insights into the Regulation of Transcription Initiation of DNA Gyrase and Role of Transcription Factor Gre from Mycobacterium tuberculosis
Genus Mycobacterium comprises a large number of species including many pathogens such as Mycobacterium leprae, Mycobacterium abscessus and Mycobacterium tuberculosis (Mtb), the last one is the causative agent of the fatal ... -
Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis
The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ...