Microbiology and Cell Biology (MCB): Recent submissions
Now showing items 161-180 of 267
-
Characterization of an In Vitro Transcription System for Peste Des Petits Ruminants Virus and Functional Characterization of RNA Triphosphatase Activity of RNA Dependent RNA Polymerase Protein L
(2018-03-03)Peste des petits ruminants virus (PPRV) belongs to the family paramyxoviridae which comprises non segmented negative sense RNA viruses including measles and rinderpest virus. PPRV is the causative agent of peste des petits ... -
Studies on Interactions between ARE Binding Proteins and Splicing Factors and their Role in Altered Splicing of PDGF-B ORF
(2018-03-03)Pre-mRNA splicing is an important level in posttranscriptional gene regulation that is essential for accurate protein synthesis and generating protein diversity. The abundance of cryptic splice sites and long intronic DNA ... -
Map-based Cloning and Characterization of TARANI, a Global Regulator of Arabidopsis Development
(2018-03-02)Forward genetic screen was performed in Arabidopsis thaliana to isolate novel genes involved in leaf development. The tarani (tni) mutant was selected for further study based on its unique cup-shaped lamina with +ve Gaussian ... -
Transcription Initiation and its Regulation in Mycobacterium Tuberculosis
(2018-02-27)The ability to fine-tune gene-expression in the adverse conditions during pre and post infectious stages has contributed in no small measure to the success of Mycobacterium tuberculosis as the deadly pathogen. Multiple ... -
Racemases in Salmonella : Insights into the Dexterity of the Pathogen
(2018-02-27)Chapter -I Introduction Salmonella is a pathogen well-known for its ability to infect a wide variety of hosts and causes disease ranging from mild gastroenteritis to typhoid fever. During infection, it is exposed to a ... -
From Transformation to Therapeutics : Diverse Biological Applications of Shock Waves
(2018-02-26)Chapter–I Introduction Shock waves appear in nature whenever the different elements in a fluid approach one another with a velocity larger than the local speed of sound. Shock waves are essentially non-linear waves that ... -
Unravelling the Mechanism of Bactericidal/Permeability-Increasing Protein Expression during Bacterial Pathogenesis
(2018-02-21)Anti-microbial proteins (AMP) are the key effector arm of the innate immune system. The prevalence of AMP in single-celled eukaryotes to humans shows its importance during the course of evolution. The first report for the ... -
Epigenetic Modulators of Glioma : From miRNAs to Chromatin Modifiers
(2018-02-20)The glial cells of the brain and the peripheral nervous system retain the capacity to divide and proliferate throughout the lifespan of an individual and thereby have the propensity to give rise to the most adult neurological ... -
Response of Mycobacterium Tuberculosis to Rifampicin - A Cellular, Molecular, and Ultrastructural Study
(2018-02-15)Tee PhD thesis presents the study of the response of Mycobacterium tuberculosis, the causative agent of tuberculosis, upon prolonged exposure to lethal concentrations of the first line anti-tuberculosis drug, rifampicin. ... -
Regulation and Characterization of Transcription Factor Activator Protein-2 Alpha (AP-2α)
(2018-02-11)Introduction AP2α is a 52 kDa retinoic acid inducible and developmentally regulated activator of transcription, which binds to the DNA in a sequence-specific manner. Transcription factor AP-2α was isolated from HeLa cells ... -
Role of SIRT6 in Myofibroblast Cell Death
(2018-01-10)Cardiovascular diseases are one of the leading causes of mortality. A common denominator across most of the cardiovascular diseases like diabetic cardiomyopathy, hypertrophic cardiomyopathy, myocardial infarction and dilated ... -
The Role of Initiation Factor 3 : Insights from E. Coli, Mitochondria and Mycoplasma
(2018-01-07)The process of translation initiation is the most highly regulated step of protein synthesis. In bacteria, three initiation factors (IF1, IF2 and IF3) play crucial roles during initiation. IF3 acts as an anti-association ... -
Functional Characterization of Saccharomyces Cerevisiae SUB1 in Starvation Induced Sporulation Response
(2017-12-12)Among the various external signals perceived by yeast cells, nutrient availability is a condition to which these cells show a highly diverse biological response. Diploid cells in response to different nutritional stress ... -
Unique Response and the Survival Mechanism of Mycobacterial Subpopulations against Oxidative and Nitrite Stress
(2017-12-03)Mycobacterial populations are known for the heterogeneity in terms of cell size, morphology, and metabolic status, which are believed to help the population survive under stress conditions. Such population heterogeneity ... -
Identification, Structural and Functional Characterisation of the Molecule that Induces Asymmetric Cell Division in Mycobacteria
(2017-12-03)Phenotypic heterogeneity in terms of cell size, morphology, and metabolic status, which are believed to help the population survive under stress conditions, is known in mycobacterial populations. Such population heterogeneity ... -
Delineating the Role of OsMADS1 in Auxin Distribution, Floret Identity and Floret Meristem Determinacy
(2017-12-02)Rice have highly derived florets borne on a short branch called ‘spikelet’ comprised of a pair of rudimentary glumes and sterile lemma (empty glumes) that subtends a single fertile floret. The floral organs consist of a ... -
Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing
(2017-11-29)Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ... -
Studies on Molecular Targets and Pathways Regulated by Rice RFL for Flowering Transition and Panicle Development
(2017-11-28)LFY of Arabidopsis is a member of a unique plant specific transcription factor family. It is involved in giving meristem a determinate floral fate by the activation of floral organ identity genes and preventing inflorescence ... -
How Much Initiator tRNA Does Escherichia Coli Need?
(2017-11-27)The work discussed in this thesis deals with the significance of initiator tRNA gene copy number in Escherichia coli. A summary of the relevant literature discussing the process of protein synthesis, ... -
Regulation of Leaf Margin Development by TOOTH/MIR160A in Arabidopsis Thaliana
(2017-11-13)TOOTH/MIR160A regulates leaf margin outgrowth in Arabidopsis thaliana Unlike animals, a striking aspect of the plant development is that they have evolved a flexible pattern of post embryonic development. This exposes ...