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Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis
(2018-04-11)
Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known ...
DNA Repair Proteins in Mycobacteria and their Physiological Importance
(2018-03-09)
DNA repair proteins in mycobacteria and their physiological importance
Mycobacterium tuberculosis, the causative organism of tuberculosis, resides in the host macrophages where it is subjected to a plethora of stresses ...
Proteomic Approaches to Study Glioma Development, Progression and Therapy
(2018-04-02)
Astrocytoma, the tumor of astrocytic origin, accounts for about 60 % of the primary
brain tumors. As per World Health Organization grading system, astrocytoma is classified as circumscribed astrocytoma (Grade I; pilocytic ...
Structure-Function Correlative Studies On The Biochemical Properties (Polymerisation, GTP binding, GTPase) Of Mycobacterial Cytokinetic Protein FtsZ In Vitro
(2010-03-26)
FtsZ, the principal cell-division protein, polymerizes in GTP-dependent manner in vitro (Bramhill and Thompson, 1994; Mukherjee and Lutkenhaus, 1994; Rivas et al., 2000). FtsZ polymerization at the mid-cell site of bacterium ...
Role of DNA Methylation in Glioblastoma Development
(2018-04-11)
Glioblastoma (GBM) is the most common and malignant of the glial tumors. These tumors may develop from lower-grade astrocytomas (diffuse astrocytoma; grade II or anaplastic astrocytoma; grade III) through a progressive ...
Epigenetic Modulators of Glioma : From miRNAs to Chromatin Modifiers
(2018-02-20)
The glial cells of the brain and the peripheral nervous system retain the capacity to divide and proliferate throughout the lifespan of an individual and thereby have the propensity to give rise to the most adult neurological ...
Studies On Initiator tRNA Selection On The Ribosomes In Escherichia Coli
(2009-05-06)
The studies reported in this thesis address the aspects of initiator tRNA selection in Escherichia Coli. A summary of the relevant literature discussing the process of ptotein biosynthesis in general and initiator tRNA ...
Mechanism Of mom Gene Transactivation By Transcription Factor C Of Phage MU
(Indian Institute of Science, 2007-04-26)
Regulation of transcription initiation is the major determining event employed by the cell to control gene expression and subsequent cellular processes. The weak promoters, with low basal transcription activities, are ...
Response of Mycobacterium Tuberculosis to Rifampicin - A Cellular, Molecular, and Ultrastructural Study
(2018-02-15)
Tee PhD thesis presents the study of the response of Mycobacterium tuberculosis, the causative agent of tuberculosis, upon prolonged exposure to lethal concentrations of the first line anti-tuberculosis drug, rifampicin. ...
Regulation and Characterization of Transcription Factor Activator Protein-2 Alpha (AP-2α)
(2018-02-11)
Introduction
AP2α is a 52 kDa retinoic acid inducible and developmentally regulated activator of
transcription, which binds to the DNA in a sequence-specific manner. Transcription factor AP-2α was isolated from HeLa cells ...