Centre for Neuroscience (CNS): Recent submissions
Now showing items 21-34 of 34
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Regulation of Lateral Mobility of Amyloid Precursor Protein by an Alzheimer’s Disease Risk Gene: Picalm
Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ... -
Novel Therapeutic Targets for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impaired memory and other cognitive deficits. Even though the genes associated with familial AD were discovered more than three decades ... -
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ... -
Structure-Function Analysis of Focal Adhesion Protein Vinculin in Neocortical Axon Growth and Development
Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ... -
Super-Resolution Imaging Reveals Localization and Regulation of Nanoscale Machinery Involved in the Amyloidogenic Pathway
Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ... -
Is Spatial Map Shaped by Environmental Determinants?
Humans and other animals form internal mental maps of the outer world in order to navigate. Hippocampal place cells and grid cells in MEC (medial entorhinal cortex) are the key components of this navigation system. However, ... -
Computational Mechanisms Underlying the Voluntary Control of Reach Movement Planning and Execution
In everyday life we make a variety of reaching movements. Most of these reaching movements have a clear objective of bringing the hand to the spatial location of the object of interest. Although we typically do not explicitly ... -
Maternal Immune Activation Perturbs Gene Expression in the Embryonic Brain Leading to Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) constitutes a spectrum of developmental disorders that share common phenotypes of social and communication deficits and repetitive behaviours. ASDs have many possible underlying causes ... -
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ... -
Factors Regulating Cerebellar Granule Neuron Progenitor Proliferation
Cerebella granule neuron progenitors (CGNPs) give rise to a homogenous group of neurons called the cerebellar granule neurons in the developing cerebellum (a hindbrain structure classically associated with fine motor ... -
Mechanisms of Dopaminergic Neurodegeneration in Parkinson's Disease
(2018-07-18)Parkinson’s disease (PD) is a debilitating movement disorder. The cardinal symptoms of PD are bradykinesia, resting tremors and rigidity. PD is characterized by degeneration of dopaminergic neurons of A9 region, substantia ... -
Dynamics of Invariant Object Representations in the Monkey Inferotemporal Cortex
(2018-06-18)Vision is computationally challenging because objects in the real world can change in size, position, viewpoint etc., and therefore cast a myriad images on the retina. Viewpoint changes are particularly challenging because ... -
The Role of Cytoskeletal Morphology in the Nanoorganization of Synapse
(2018-01-10)Synapse is the fundamental unit of synaptic transmission. Learning, memory and neurodegenerative diseases of the brain are attributed to the maintenance and alteration in synaptic connections. The efficiency for synaptic ... -
Evaluation of Early Pathogenic Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
(2017-12-07)Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder in the elderly, characterized by severe loss of memory and higher cognitive functions. In the hundred years since its discovery, Alzheimer’s ...