In this thesis, we investigate behavioural mechanisms and neural substrates of distinct components of endogenous spatial attention. Endogenous attention facilitates neural processing of the selected stimulus through one ...

The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ...

Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ...

Amyloid beta, a key determinant in the pathology of Alzheimer's disease (AD), is formed by the sequential proteolysis of Amyloid Precursor Protein (APP) by β-and γ-secretase. Evidence over the last few decades indicates ...

Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around the recording electrode that contributes to the electrical activity recorded by the electrode. More specifically, ...

The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ...

The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ...

In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...

Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ...

Specialized sensory regions process incoming sensory inputs using a variety of mechanisms, such as normalization and excitatory-inhibitory interactions. These mechanisms can be studied through induced and evoked oscillations, ...