Browsing Centre for Neuroscience (CNS) by Subject "Research Subject Categories::NATURAL SCIENCES::Biology"
Now showing items 1-5 of 5
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Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ... -
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around the recording electrode that contributes to the electrical activity recorded by the electrode. More specifically, ... -
Qualitative similarities and differences between monkey and human visual perception
Animal models play a crucial role in helping neuroscientists unravel the computations supporting behaviour at the resolution of a single neuron in the brain. In vision science, the macaque monkey is the pre-eminent model ... -
Role of Mint family of Proteins in the nanoscale localization and real-time retention of surface Amyloid Precursor
Amyloid beta, a key determinant in the pathology of Alzheimer's disease (AD), is formed by the sequential proteolysis of Amyloid Precursor Protein (APP) by β-and γ-secretase. Evidence over the last few decades indicates ... -
Use of Human Induced Pluripotent Stem Cells as a Model to Study Primary Microcephaly
The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ...