Browsing Department of Bioengineering (BE, Earlier known as BSSE) by Title
Now showing items 15-34 of 41
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Engineering 3D Organotypic Models for the Study of Breast Cancer Metastasis
Breast cancer is the most common form of cancer among women the world over. Metastasis, or, the spreading of the primary tumor to other vital organs, is the major cause of mortality in breast cancer. Metastasis is a ... -
Engineering Disease Models for Cardiac and Skeletal Muscle Tissues
Biomedical research aims to gain deeper insights into the mechanisms of human pathophysiology to develop improved therapies and diagnostics. Despite significant advances made in the understanding and treatment of human ... -
Engineering Graphene Oxide Surface Chemistry and Investigating Its Effect on The Physicochemical and Biological Properties
In the current study, systematic tuning of oxidation degree of GO has been explored and a two-step methodology for engineering GO surface chemistry was successfully developed. The investigation of the effects of oxidation ... -
Engineering three-dimensional hydrogel culture systems to delineate host-pathogen interaction in tuberculosis
Full text embargo up to 25/5/2026 Mycobacterium tuberculosis (Mtb), an obligate human pathogen, spreads through aerosols to the lung alveoli, where alveolar macrophages engulf it. These macrophages then migrate to the ... -
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ... -
Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ... -
Helical Magnetic Nanomotors Fabrication, Toxicity and Therapeutics
The 21st century dawned with remarkable advances in the controlled motion of nanoparticles. These particles could be manipulated through external energy sources (chemical, magnetic, acoustic, or biological), resulting in ... -
Immune cell surveillance and death on silicone catheter surfaces drives bacterial biofilm formation
Silicone venous catheters are among the most used medical devices in the world with a prevalence of up to 80% in hospitalised patients. While they are used for several life-saving applications, they are also prone to ... -
Improving Healing Outcomes in Diabetic Wounds by Understanding and Modulating Immune Responses
Diabetic Foot Ulcers (DFUs) are chronic wounds that show delayed or absence of healing in individuals with diabetes. Currently, diabetic wounds are managed clinically through regular debridement, pressure off-loading, ... -
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ... -
Integrating Computational Tools and Models to Study Positive-sense RNA Virus Lifecycle
Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ... -
Intra- and inter-cellular drivers of Epithelial-Mesenchymal heterogeneity in cancer cells
Phenotypic heterogeneity is a fundamental feature reported across prokaryotic and eukaryotic cells. This heterogeneity enables an isogenic cell population to be composed of distinct subpopulations with varying functional ... -
Investigation of cell membrane dynamics: A potential marker for lipid response towards membrane-active proteins and peptides
The cell membrane is made up of lipids and proteins held together with intermolecular hydrophobic/hydrophilic interactions. These physical non-covalent interactions help in maintaining the integrity of the cell membrane, ... -
Investigations into the changes in biomechanics of liver cells upon HCV infection
Biomechanics is an important regulator of cell function. Active (external forces) as well as passive (substrate stiffness) mechanical stimuli from the cell microenvironment can alter fundamental aspects of cell function ... -
Mechanistic insights into the effects and applications of shockwaves in prokaryotic and eukaryotic organisms
Shock waves are non-linear waves propagating at speeds greater than the speed of sound, with a unique characteristic of instantaneously increasing the pressure, temperature and density of the medium through which they ... -
Micro-carriers mediated bacteriophage delivery for targeting intracellular Mycobacterium tuberculosis infection and TB prevention
Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ... -
Molecular determinants of self-assembly of the pore forming toxin Cytolysin A
Pore forming toxins (PFTs) belong to a class of bacterial exotoxins that disrupt the biological membrane barrier by formation of nanopores. These toxins are central to the virulence of pathogens such as S. pneumoniae, ... -
Multistability in cellular differentiation enabled by three and four node mutually repressive regulatory networks: A case study of CD4+ T-cell decision making
Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ... -
New Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffolds
Aging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement ... -
PLGA Based Drug Carriers for Treatment of Osteoarthritis
Osteoarthritis (OA) has affected nearly 22-39% of the Indian population and remains one of the most common musculoskeletal disorders that affects articular joints. Post-traumatic osteoarthritis, which develops following ...