Browsing Department of Bioengineering (BE, Earlier known as BSSE) by Title
Now showing items 10-29 of 41
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Delineating the dynamics of neutrophil response in multiple inflammatory stimuli and its consequences
In this thesis, we investigate the regulation of neutrophils, an important component of the immune system, and its implications on inflammation and pathological conditions. We use biomaterial implants to induce chronic ... -
Design and Development of a Semi-automated System for Electro-thermo-mechanical (Etm) Phenotyping of Breast Tissues Ex-vivo
Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ... -
Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ... -
Development of anti-infective therapy against intracellular pathogens using targeted particulate delivery systems
Pathogens from bacterial class: Salmonella, Mycobacterium tuberculosis, Listeria can survive and replicate intracellularly. While some pathogens remain cytosolic others such as Salmonella and Mycobacterium tuberculosis ... -
Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum
Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ... -
Engineering 3D Organotypic Models for the Study of Breast Cancer Metastasis
Breast cancer is the most common form of cancer among women the world over. Metastasis, or, the spreading of the primary tumor to other vital organs, is the major cause of mortality in breast cancer. Metastasis is a ... -
Engineering Disease Models for Cardiac and Skeletal Muscle Tissues
Biomedical research aims to gain deeper insights into the mechanisms of human pathophysiology to develop improved therapies and diagnostics. Despite significant advances made in the understanding and treatment of human ... -
Engineering Graphene Oxide Surface Chemistry and Investigating Its Effect on The Physicochemical and Biological Properties
In the current study, systematic tuning of oxidation degree of GO has been explored and a two-step methodology for engineering GO surface chemistry was successfully developed. The investigation of the effects of oxidation ... -
Engineering three-dimensional hydrogel culture systems to delineate host-pathogen interaction in tuberculosis
Full text embargo up to 25/5/2026 Mycobacterium tuberculosis (Mtb), an obligate human pathogen, spreads through aerosols to the lung alveoli, where alveolar macrophages engulf it. These macrophages then migrate to the ... -
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ... -
Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ... -
Helical Magnetic Nanomotors Fabrication, Toxicity and Therapeutics
The 21st century dawned with remarkable advances in the controlled motion of nanoparticles. These particles could be manipulated through external energy sources (chemical, magnetic, acoustic, or biological), resulting in ... -
Immune cell surveillance and death on silicone catheter surfaces drives bacterial biofilm formation
Silicone venous catheters are among the most used medical devices in the world with a prevalence of up to 80% in hospitalised patients. While they are used for several life-saving applications, they are also prone to ... -
Improving Healing Outcomes in Diabetic Wounds by Understanding and Modulating Immune Responses
Diabetic Foot Ulcers (DFUs) are chronic wounds that show delayed or absence of healing in individuals with diabetes. Currently, diabetic wounds are managed clinically through regular debridement, pressure off-loading, ... -
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ... -
Integrating Computational Tools and Models to Study Positive-sense RNA Virus Lifecycle
Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ... -
Intra- and inter-cellular drivers of Epithelial-Mesenchymal heterogeneity in cancer cells
Phenotypic heterogeneity is a fundamental feature reported across prokaryotic and eukaryotic cells. This heterogeneity enables an isogenic cell population to be composed of distinct subpopulations with varying functional ... -
Investigation of cell membrane dynamics: A potential marker for lipid response towards membrane-active proteins and peptides
The cell membrane is made up of lipids and proteins held together with intermolecular hydrophobic/hydrophilic interactions. These physical non-covalent interactions help in maintaining the integrity of the cell membrane, ... -
Investigations into the changes in biomechanics of liver cells upon HCV infection
Biomechanics is an important regulator of cell function. Active (external forces) as well as passive (substrate stiffness) mechanical stimuli from the cell microenvironment can alter fundamental aspects of cell function ... -
Mechanistic insights into the effects and applications of shockwaves in prokaryotic and eukaryotic organisms
Shock waves are non-linear waves propagating at speeds greater than the speed of sound, with a unique characteristic of instantaneously increasing the pressure, temperature and density of the medium through which they ...