• 4D Printing of Polymer Composites to Engineer Resorbable and Deployable Implants 

  Choudhury, Saswat

  Medical implants include products that are used to replace or restore the function of any damaged organ or tissue inside the body. The current generation of implants are mostly made from non-degradable materials and are ...

• Multistability in cellular differentiation enabled by three and four node mutually repressive regulatory networks: A case study of CD4+ T-cell decision making 

  Duddu, Atchuta Srinivas

  Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ...

• Integrating Computational Tools and Models to Study Positive-sense RNA Virus Lifecycle 

  Chhajer, Harsh

  Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ...

• Bacterial cellular heterogeneity in inducible gene expression and drug susceptibility 

  Ratnasri, K

  Biological processes are inherently noisy, and such stochasticity can result in significant cell to cell variability in isogenic bacterial populations. Functionally, cellular heterogeneity can have significant impact on ...

• Biophysics of focal adhesion and cytoskeletal remodeling under fluid shear 

  Paddillaya, Neha

  Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ...

• New Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffolds 

  Yadav, Parul

  Aging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement ...

• Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa 

  Badal, Divakar

  Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ...

• Micro-carriers mediated bacteriophage delivery for targeting intracellular Mycobacterium tuberculosis infection and TB prevention 

  Sharma, Pallavi Raj

  Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ...

• Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum 

  Subbalakshmi, A R

  Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ...

• Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis 

  Hari, Kishore

  Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ...

• Delineating the dynamics of neutrophil response in multiple inflammatory stimuli and its consequences 

  Alakesh

  In this thesis, we investigate the regulation of neutrophils, an important component of the immune system, and its implications on inflammation and pathological conditions. We use biomaterial implants to induce chronic ...

• Design and Development of a Semi-automated System for Electro-thermo-mechanical (Etm) Phenotyping of Breast Tissues Ex-vivo 

  Anil Vishnu, G K

  Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ...

• Resolvin D1-loaded Liposomal Nanocarriers for the Treatment of Osteoarthritis 

  Dravid, Ameya

  Osteoarthritis (OA) is the most common disorder of the joints and currently affects >300 million patients worldwide. In this disease, the articulating cartilage undergoes progressive damage which leads to severe pain and ...

• Analysis of vocal sounds in asthmatic patients 

  Yadav, Shivani

  Around 334 million people have asthma worldwide. Asthma is an inflammatory disease of the airways which causes cough, breathlessness, chest tightness, and other peculiar sounds during breathing. The golden standard test ...

• Improving Healing Outcomes in Diabetic Wounds by Understanding and Modulating Immune Responses 

  Vijaya Raghavan, Jayashree

  Diabetic Foot Ulcers (DFUs) are chronic wounds that show delayed or absence of healing in individuals with diabetes. Currently, diabetic wounds are managed clinically through regular debridement, pressure off-loading, ...

• Helical Magnetic Nanomotors Fabrication, Toxicity and Therapeutics 

  Reshma, V R

  The 21st century dawned with remarkable advances in the controlled motion of nanoparticles. These particles could be manipulated through external energy sources (chemical, magnetic, acoustic, or biological), resulting in ...

• Towards a Better Understanding of the Interaction between Phagocytic Immune Cells and Synthetic Particulates 

  Sharma, Preeti

  Particulate technology has transformed the field of diagnostic and therapeutic medicine due to the ability of particulates to provide better contrast in various imaging modalities and improve the targeting of therapeutic ...

• Role of Fiber Orientations in the Mechanobiology of Cells under Stretch 

  Chatterjee, Aritra

  Fiber reinforcement plays an important role in the structure and function of biological materials. Soft connective tissues in human body like artery, heart tissues, skin etc. exhibit anisotropic material responses due to ...

• PLGA Based Drug Carriers for Treatment of Osteoarthritis 

  Kaamini, M D

  Osteoarthritis (OA) has affected nearly 22-39% of the Indian population and remains one of the most common musculoskeletal disorders that affects articular joints. Post-traumatic osteoarthritis, which develops following ...

• Mechanistic insights into the effects and applications of shockwaves in prokaryotic and eukaryotic organisms 

  Datey, Akshay

  Shock waves are non-linear waves propagating at speeds greater than the speed of sound, with a unique characteristic of instantaneously increasing the pressure, temperature and density of the medium through which they ...

View more