Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...

One year embargo upto 20/2/2026 RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ...

The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ...

Erythrocytes are specialized cells that perform the crucial function of gas exchange in all vertebrates. Regulation of gene expression was believed to be absent in these cells due to the absence of nucleus. It was also ...

In certain mRNAs ribosomes continue translation beyond the canonical stop codon to generate longer isoform with a C-terminal extension. This phenomenon is termed stop codon readthrough (SCR). Previously, a genome-wide ...

DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ...

The present study aims to elucidate the physiological role of plant DJ-1 homologs in Arabidopsis thaliana under various abiotic stress conditions. It seeks to provide deeper insights into the diverse functions of plant ...

Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ...

Robust CD8 T cell activity is crucial for anti-tumor immune response. CD8 T cells keep tumors in check using direct effector mechanisms that cause tumor death. The key to this activity is the recognition of tumor cells as ...