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    Browsing Biochemistry (BC) by Title

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      • Regulation of carbon metabolism in Pichia pastoris by Mxr1p and identification of novel regulators 

        Gupta, Aditi
        Pichia pastoris (a.k.a. Komagataella phaffii), a widely used yeast for recombinant protein production, is cultured under a variety of conditions ranging from shake flasks to large bioreactors employing minimal, chemically ...
      • Regulation of Flagellar Motility in Giardia lamblia and Trichomonas vaginalis 

        Sudhakar, Aparna
        Protozoan pathogens are responsible for infections that are highly prevalent, especially in developing and under-developed countries. Flagellar motility is exhibited by a variety of organisms ranging from bacteria to certain ...
      • Regulation of RecA nucleoprotein filament stability by RecX and the effects of RecA-membrane interaction on the activities of RecA in mycobacteria 

        Prasad, Deepika
        E. coli RecA is a multifunctional protein known to be associated with the cell membrane, forming foci often located at the cell poles, which gets redistributed along the length of the cell during SOS response. Several lines ...
      • A role for the cohesin complex in subtelomeric gene silencing in Saccharomyces cerevisiae 

        Kothiwal, Deepash
        Chromatin is a dynamic structure which reorganizes to support numerous chromosomal processes. Various histone and non-histone proteins are involved in chromatin organization. One such group of non-histone proteins, known ...
      • Role Of Cysteine Residues And Target Base Eversion In M.EcoP151 Mediated Methyl Transfer Reaction 

        Reddy, Yeturu Venkatarami (2012-02-22)
      • Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures 

        Shukla, Kaustubh
        G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede replication ...
      • Role of Grp 75 Chaperone Folding Machinery in the Maintenance of Mitochondrial Protien Quality Control 

        Goswami, Arvind Vittal (2018-04-03)
        My research focuses on understanding the importance of human mitochondrial Hsp70 (Grp75) chaperone machinery for the maintenance of protein quality control inside the mitochondrial matrix. The investigations carried out ...
      • Role of Mammalian RAD51 Paralogs in Genome Maintenance and Tumor Suppression 

        Somyajit, Kumar (2018-01-28)
        My research was focused on understanding the importance of mammalian RAD51 paralogs in genome maintenance and suppression of tumorigenesis. The investigation carried out during this study has been addressed toward gaining ...
      • Role of mammalian RAD51 paralogs in replication stress response and genome maintenance 

        Saxena, Sneha
        The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has ...
      • Role of Mycobacterium tuberculosis DinG and UvrD helicases in unwinding G-quadruplex DNA 

        Ambika, D
        Recent studies have demonstrated the role of E. coli UvrD as a replicative helicase that facilitates replication of rolling circle plasmids. Along with dinG and rep helicase, UvrD a so-called “accessory helicase” removes ...
      • Role of Mycobacterium Tuberculosis RecG Helicase in DNA Repair, Recombination and in Remodelling of Stalled Replication Forks 

        Thakur, Roshan Singh (2018-05-14)
        Tuberculosis, caused by the infection with Mycobacterium tuberculosis remained as a major global health challenge with one third of world population being infected by this pathogen. M. tuberculosis can persist for decades ...
      • Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures 

        Saha, Tias
        Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...
      • Role of RTEL1 helicase in the regulation of homologous recombination during DNA replication 

        Dixit, Suruchi Dayanand
        Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ...
      • The Role of Saccharomyces Cerevisiae MRX Complex and Sae2 in Maintenance of Genome Stability 

        Ghodke, Indrajeet Laxman (2018-06-11)
        In eukaryotes, the repair of DSBs is accomplished through two broadly defined processes: Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). The central step of HR is pairing and exchange of strands between ...
      • Roles Of CTLA4(CD 152)-CD80/CD86 Costimulatory Interactions In Modulation Of Primary Mouse CD4' T Cell Cycle Progression And Survival 

        Mukherjee, Sambuddho (2011-05-04)
      • Roles Of Interferon-Modulated Genes In Cell Surface Expression Of Major Histocompatibility Complex Encoded Class I Molecules And Cell Survival In The Hepatoma Cell Line, H6 

        Prasanna, S Jyothi (2011-08-19)
      • Roles of Protein Acetylation in the Human Pathogen Helicobacter pylori 

        Kumar, Amrendra
        Helicobacter pylori is a gram-negative epsilon proteobacterium infecting half of the world population. H. pylori is a naturally competent bacterium with a huge repertoire of Restriction-Modification (RM) systems. The ...
      • Selective Binding Of Meiosis-Specific Yeast Hop1 Protein, or Its ZnF Motif, To The Holliday Junction Distorts The DNA Structure : Implications For Junction Migration And Resolution 

        Tripathi, Pankaj (2010-09-30)
        Saccharomyces cerevisiae HOP1, which encodes a component of the synaptonemal complex, plays an important role in both gene conversion and crossing over between homologs, as well as enforces the meiotic recombination ...
      • Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology 

        Lekha, E M
        Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ...
      • Stop codon readthrough of NNAT mRNA and its role in neuronal differentiation 

        Pandit, Madhuparna
        Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ...

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