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    Browsing Biochemistry (BC) by Title

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      • Identification and Biochemical Characterization of Novel Inhibitors of Nonhomologous End Joining: Implications in DNA Double-Strand Break Repair and Cancer Therapy 

        Ray, Ujjayinee
        To summarize, in the present study, we have synthesized and characterized three novel NHEJ inhibitors targeting DNA Ligase IV, with several fold better efficacy compared to SCR7 and thus potential to be developed as cancer ...
      • Identification And Characterisation Of Two Silencing Barrier Sequences In Saccharomyces Cerevisiae 

        Biswas, Moumita (2010-07-21)
        In eukaryotic cells, genomic DNA exists as chromatin in association with histone octamers called nucleosomes, and various other chromatin proteins. Chromatin structure varies along the chromosome and this influences the ...
      • Identification And Characterization Of A Virus Inducible Non Coding RNA (VINC) 

        Sreenivasa Murthy, U M (2010-12-29)
        Non-protein coding eukaryotic genome sequences often referred to as junk DNA are estimated to encode several non-coding RNAs (ncRNAs) which may account for nearly 98% of all genomic output in humans. The output of such a ...
      • Identification Of Chloroquine Resistant Haplotypes Of Plasmodium Falciparum In India And Development Of New Antimalarial Combinations 

        Vathsala, P G (2008-10-03)
        Malaria afflicts 300-500 million people in the world and the mortality ranges from 1-2 million, children in Africa being the most susceptible. With a vaccine not being available against malaria and the front line drugs ...
      • Identification Of Key DNA Elements Involved In promoter Recognition By Mxr1p , A key Regulator Of Methanol Utilisation Pathway In Pichia Pastoris 

        Kranthi, Balla Venkata (2010-04-09)
        The methylotrophic yeast Pichia pastoris is widely used for recombinant protein production due to its ability to grow to high cell densities as well as possession of an inducible methanol utilization pathway (MUT). The ...
      • Identification Of Novel MLH 1p Interacting Proteins By Biochemical And Genetic Methods 

        Kumaran, M (2011-05-04)
      • Identification of the Minimal Domain of RNA Trihosphastase Activity in the L Protien of Rinderpest Virus and Charecterization of its Enzymatic Activities 

        Singh, Piyush Kumar (2018-04-03)
        Morbilliviruses belong to the family Paramyxoviridae of the Mononegavirale order of viruses. The Mononegavirale order contains viruses which contain negatively-polar, non-segmented and single stranded RNA genomes. This ...
      • Identification of Tropomyosin as the Major Cross-Reacting Crustacean Allergen 

        Shanti, K.N. (Indian Institute of Science, 2005-04-25)
        Seafood including crustaceans, on ingestion, are known to provoke gastrointestinal as well as systemic allergic reactions. Crustaceans are aquatic arthropods with a chitinous exoskeleton and include shrimp, lobster, prawn ...
      • Immunochemical Studies on the family of Biotin Binding Proteins 

        Subramanian, N (Indian Institute of Science, 2005-04-29)
        Investigations detailed in this thesis constitue a part of continuing programme of research work undertaken in this laboratory on vitamin binding proteins. Avidin from the chicken egg white, streptavidin &om the bacterium ...
      • Immunochemical Studies On The Major Cross-Reacting Allergens From The Pollen Of Parthenium Hysterophorous 

        Gupta, Neetu (2013-06-13)
      • Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection 

        Dixit, Akanksha (2018-06-15)
        Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ...
      • Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality 

        Pathak, Sanmoy
        Immunomodulation is a process by which the immune response of the host is either enhanced or suppressed due to various factors which either protects or makes the host more susceptible to particular diseases. Immunomodulators ...
      • Immunoneutralization Of Cytotoxic Abrin : Insights Into Mechanisms And Therapy 

        Bagaria, Shradha (2015-12-02)
        Type II Ribosome Inactivating Proteins (RIPs), commonly known as A/B toxins are heterodimers comprising of a catalytically active A chain, an RNA N-glycosidase which inhibits protein synthesis and a lectin-like B chain ...
      • Implications of Soluble Diacylglycerol Acyltransferases in Triacylglycerol Biosynthesis in Yeast and Plants 

        Sapa, Hima Rani (2018-04-12)
        Lipids are stored in a cell for providing energy. The main advantages of storing lipids over carbohydrates like glycogen is that, lipids yield more energy after oxidation because they represent the highly reduced form of ...
      • In vitro Studies Towards Understanding The Function And Aggregation Properties Of Escherichia Coli RecA Protein 

        Mahalakshmi, S (2012-11-09)
      • In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia 

        Tushir, Sheetal
        Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...
      • Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule 

        Shwetank, * (2018-04-24)
        Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a ...
      • Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis 

        Yadav, Priya
        Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ...
      • Insights Into Oxidative Folding Of Retinol Binding Protein In The Endoplasmic Reticulum : A Study In Isolated Microsomes 

        Rajan, Sundar S (2009-04-30)
        The central role played by the Endoplasmic Reticulum (ER) in the correct folding and assembly of secretary and membrane proteins cannot be overstated. As the first compartment in the secretary pathway, it is responsible ...
      • Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin 

        Tiwari, Vinita
        Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ...

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