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    Browsing Biochemistry (BC) by Title

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      • Studies On Heat Shock Protein 60 From Plasmodium Falciparum 

        Padma Priya, P (2010-09-14)
        Malaria is caused by a protozoan parasite belonging to the genus Plasmodia. Plasmodium falciparum is responsible for the fatal form of human malaria. Spread of drug resistant parasites warrants for sound biological ...
      • Studies on inflammatory responses: Roles of Interferon-gamma in macrophage activation and Nitric oxide synthase 2 during Salmonella Typhimurium infection-induced sepsis 

        Yadav, Shikha
        Inflammation is a complex set of immune responses that is critical for survival during injury or infection. It is also crucial for maintenance of tissue homeostasis under myriad conditions caused by cellular stress and ...
      • Studies on Novel Functional Responses of Mouse Peritoneal Macrophages to Interferon-gamma : Roles of Nitric Oxide Synthase 2 

        Chandrasekar, Bhagawat S (2018-04-18)
        Interferons are known cytokines that display antiviral, anti-proliferative and immuno-modulatory functions in the host. Interferon-gamma (Ifnγ) is the only type II family interferon that binds to the heterodimeric receptor ...
      • Studies On Polypyrimidine Tract Binding Protein : Identification Of Interacting Partners 

        Ramesh, V (2010-03-26)
        PTB (HnRNP I) is a multifunctional RNA binding protein which participates in a variety of RNA metabolic processes put together called as post transcriptional gene regulation. It interacts with shuttling hnRNPs L, K and E2 ...
      • Studies On The Functional Roles Of Peptidase N, A M1 Family Member, During Stress And Infection 

        Bhosale, Manoj (2014-08-11)
        The cytosolic protein degradation pathway, performed by ATP-dependent proteases and ATP-independent peptidases, plays important roles in several cellular activities, e.g. cell division, cell cycle progression, intracellular ...
      • Studies On The Mechanisms Involved In Thymic Atrophy During Salmonella Enterica Serovar Typhimurium Infection 

        Deobagkar-Lele, Mukta (2015-09-04)
        T lymphocytes are an essential component of the adaptive immune response and are highly versatile in function. Each T cell has a unique T cell receptor that can recognize an antigenic peptide in the context of the major ...
      • Studies On The Molecular Mechanism Of Cytokinin Action: Involvement Of Ca2+, Protein Kinase And Concurrent Protein Synthesis In Signaling Of Cytokinin-Induced Expression Of Pathogenesis-Related Enzymes In Cucumber 

        Barwe, Sonali P (Indian Institute of Science, 2005-12-08)
        Phytohormones act as signals to regulate plant growth and development by modulation of gene expression in response to internal developmental cues or external environmental stimuli, such as light and pathogen infection. ...
      • Studies on the post-transcriptional regulation of genes of glutamate utilization pathway in Pichia pastoris and a role for Retrograde regulation protein 1 

        Dey, Trishna
        The methylotrophic yeast, Pichia pastoris can utilize compounds such as glucose, glycerol, methanol, acetate, amino acids, or oleic acid as the sole source of carbon. However, the regulation of synthesis of key enzymes of ...
      • Studies On The Roles Of Intracellular Ca2+ And Reactive Oxygen Species During CD4+ T Cell Activation : Influence Of Signal Strength 

        Ahmed, Asma (2011-03-08)
        Optimal CD4+ T cell activation is key to the generation of a productive immune response. Naïve circulating CD4+ T cells are quiescent under normal conditions and undergo activation only upon encounter of the T cell receptor ...
      • Studies on the roles of rffG and rfbB encoding dTDP-glucose 4,6- dehydratase in Salmonella Typhimurium 

        Chakraborty, Subhashish
        Salmonellosis is a major health concern which causes significant morbidity and mortality worldwide. Infection with Salmonella Typhimurium leads to self-limiting diarrhea in healthy individuals and invasive disease in ...
      • Study of Ca2+-Mediated Signal Transduction During Embryogenesis In Sandalwood (Santalurm Album L.) And Characterization Of An Early Development-Specific CDPK 

        Anil, Veena S (Indian Institute of Science, 2005-12-08)
        Calcium ion plays a pivotal role as second messenger during signal/response coupling in plant cells (Trewavas, 1999). Elevations of cytosolic Ca2+ occur in plants as a consequence of abiotic and biotic stresses, environmental ...
      • A Study On The Roles Of The Ras Activation Pathway During Interferonγ Mediated Functional Responses And Acetaminophen-induced Liver Injury In Mice 

        Saha, Banishree (2010-12-07)
        Interferons (IFNs) perform a wide range of biological activities: anti-microbial, anti-proliferative, immunomodulatory etc. The IFN family includes three main classes: Type I, Type II and the recently identified Type III. ...
      • Study To Map The Functional Domain Of Glycodelin 

        Devasena, P (2011-08-22)
      • Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity 

        Bhattacharya, Supreet
        Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...
      • Systems biology approach to dissect Salmonella-host interactions 

        Banerjee, Pip
        Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ...
      • A systems-level exploration of host responses across the disease spectrum of Tuberculosis and COVID-19 

        Banerjee, Ushashi
        The host immune system orchestrates a defense mechanism against any invading pathogen with a combination of many mechanisms including antibody production, T-cell response, and memory response. The manner and extent of host ...
      • Targeting RAD51C Pathological Mutants by Synthetic Lethality and Extended Functions of RAD51C/XRCC3 in Mitochondrial Genome Maintenance 

        Mishra, Anup
        To counteract the potentially calamitous effects of genomic instability in the form of double-strand breaks (DSBs), cells have evolved with two major mechanisms. First, DNA non¬homologous end joining (NHEJ) which requires ...
      • Towards Elucidating The Role Of Histone H1t And Gene Expression Profiling Of Spermatogenic Cells During Mammalian Spermatogenesis 

        Sneha Ramesh, * (2011-05-03)
      • Towards precision medicine to detect, characterize and treat liver cancer: Large-scale data analyses using genome-wide networks 

        Mishra, Madhulika
        In summary, various systems biology approaches were applied to identify a potential genesignature set to monitor CLD progression which can help in the early detection of HCC. An unbiased analysis of metabolic alterations ...
      • Towards The Understanding Of The Structural Biology Of Histone H1 

        Bharath, M M Srinivas (Indian Institute of Science, 2005-11-23)
        In the eukaryotic nucleus, an immense length of DNA is compactly packaged to generate an ordered three-dimensional hierarchical structure called chromatin (van Holde, 1988; Wolffe, A.P, 1998). This organization forms a ...

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