Browsing Biochemistry (BC) by Title

Molecular Characterization Of Novel Senescent Strains Of Neurospora From India

D'Souza, Anthony Deepak (2011-05-03)

Molecular Cloning And Characterization Of A Calcium-Depdendent Protein Kinase Isoform ScCPK1 From Swainsona Canescens

Srideshikan, S M (2013-06-10)

Plants are constantly exposed to pathogens and various environmental stresses, such as cold, salinity and drought. Plants normally respond rapidly to these biotic and abiotic stresses. Efficient perception of biotic and ...

Molecular Cloning And Characterization Of Two Tropane Alkaloid Biosynthetic Enzyme cDNAs And Studies On rgs-CaM Like Gene In Datura Metel L

Pramod, K K (2011-05-02)

Molecular Genetic Analysis Of The Role Of Nse2, A SUMO E3 Ligase Of The Smc5/6 Complex, In Resisting Genotoxic Stress And Maintaining Chromosome Stability In Saccharomyces Cerevisiae

Rai, Ragini (2011-01-20)

DNA repair pathways have evolved to protect the genome from damage caused by intrinsic and extrinsic factors. Although numerous DNA repair mechanisms have been studied and reported, information regarding how they coordinate ...

Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1

Deepthi, R (2018-06-29)

The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ...

Molecular Insights Into The Architecture And Assembly Of Physalis Mottle Tymovirus

Sastri, Mira (2012-02-24)

Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells

Sabharwal, Pallavi

Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ...

Molecular Mechanisms Underlying Phosphatidylinositol-Specific Phospholipase C Mediated Regulation Of Lipid Metabolism

Rupwate, Sunny Dinkar (2016-03-04)

Phosphoinositide-specific phospholipase C (PLC) is involved in Ca2+ mediated signalling events that lead to altered cellular status. PLC activation causes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and ...

A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers

Bhosle, Amrisha

Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ...

Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers

Thakur, Chandrani

Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ...

Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris

Sahu, Umakant (2018-03-01)

The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ...

Mycobacterium Leprae RecA Intein : A LAGLIDADG Homing Endonuclease, Displays A Unique Mode Of DNA Binding And Catalysis Compared To A Canonical LAGLIDADG Homing Enzyme

Singh, Pawan (2010-09-30)

Mobile genetic elements are DNA sequences that move around to different positions within one genome or between different genomes. Mobile DNA elements were initially considered as selfish DNA sequences parasitizing the ...

Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins

Manjunath, G P (2011-04-06)

Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ...

Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors

Guhan, N (Indian Institute of Science, 2005-05-10)

Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an ...

New Anticancer Secondary Metabolites from an Endophytic Fungus Chaetomium Nigricolor Isolated from Catharanthus Roseus : Structural Elucidation and Molecular Mechanism Underlying Anticancer Effects

Geethanjali, D (2018-06-13)

Cancer has become a major health problem due to its high rate of morbidity and mortality. Severe side effects associated with most of the available anticancer drugs and the development of the drug resistant cells are the ...

New insights into the role of condensin in Saccharomyces cerevisiae

Lakshmi, Mahendrawada R

Structural Maintenance of Chromosomes (SMC) complexes are highly conserved from prokaryotes to eukaryotes. Saccharomyces cerevisiae has six SMC proteins which form three SMC-complexes in association with non-SMC subunits ...

Non-canonical functions of lymphoid-specific proteins AID and RAG1: Understanding mechanism, regulation, and implications in genomic instability

Roy, Urbi

Recombination-activating genes (RAGs) and Activation-induced cytidine deaminase (AID) are lymphoid cell-specific proteins that play crucial roles in the development of adaptive immunity. Diversification of the immune system ...