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    Browsing Biochemistry (BC) by Title

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      • Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin 

        Tiwari, Vinita
        Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ...
      • Insights Into The Hormonal Regualtion Of Epididymal Function : A Role For Estrogen 

        Deshpande, Shayu (2011-08-22)
      • Insights Into The Mechanism Of Polyprotein Processing Of Sesbania Mosaic Virus And Characterization Of The Polyprotein Domains 

        Nair, Smita (2013-06-10)
        1. Viruses are obligate parasites that hijack the host cell machinery to synthesize their own gene products and for their propagation. In order to establish a successful viral infection, viruses have evolved different ...
      • Insights Into The Trans-Splicing Based Expression Of Heat Shock Protein 90 In Giardia Lamblia 

        Rishi Kumar, N (2016-09-14)
        Heat shock proteins (Hsps) are a class of molecular chaperones which were first discovered as proteins up-regulated in response to heat stress in Drosophila. Later, it was found that these set of proteins get up-regulated ...
      • Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis 

        Swayam Prabha, * (2014-12-01)
        Introduction Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ...
      • Interactions At The Active Site Of Serine Hydroxymethyltransferases 

        Bhaskar, B (2012-12-11)
      • Interactions Of A 14 kDa β-galactoside Binding Animal Lectin With Its Ligands And Its Role In Cell-matrix Adhesion 

        Radha, V (2012-11-09)
      • Invertase in a thermophilic fungus, thermomyces lanuginosus: its unusual behaviour And regulation 

        Chaudhuri, Amitabha (Indian Institute of Science, 2005-04-25)
        The understanding of the phenomenon of thermophily requires investigations of both thermophilic prokaryotes and eukaryotes. In the eukaryotes, thermophily is exhibited only by a few species of fungi which can grow up to ...
      • Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health 

        Susarla, Gautam Ratna Kiran
        The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ...
      • Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas 

        Javadekar, Saniya M
        Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...
      • Investigation of anticancer compounds in the natural productome of marine algae associated-endophytic fungi 

        Kamat, Siya
        Cancer is one of the leading causes of death worldwide. Owing to the complex ways in which this disease develops, there is a constant demand for new drugs. Natural products have delivered great promise in inspiring ...
      • Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation 

        Nilavar, Namrata M
        In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ...
      • Isolation And Identification of Tropane Alkaloid Producing Endophytic Fungi from Datura Metel L., And Studies on Colletotrichum Boninense Recombinant Putrescine N-mehtyltransferase 

        Naik, Tanushree (2017-10-11)
        Datura metel is a herbaceous plant found in almost all tropical parts of the world. It belongs to the family Solanaceae whose members, viz. Duboisia, Atropa, Hyoscyamus and Datura plants are known to produce tropane ...
      • Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida. 

        Kashyap, Srishti
        Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ...
      • Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species 

        Taritla, Sidhartha
        Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...
      • Japanese Encephalitis Virus Infection In Vitro : Role Of Type-I Interferons And NF-kB In The Induction Of Classical And Nonclassical MHC-I Molecules 

        Abraham, Sojan (2011-03-08)
        Japanese encephalitis virus (JEV) is one of the major causes of encephalitis in Asia. JEV causes serious inflammation of the brain, which may lead to permanent brain damage and has a high mortality rate. Almost 3 billion ...
      • Kinetic, Catalytic and Epigenetic Properties of HpyAXVII DNA Methyltransferase – a Phasevarion in the Human Pathogen Helicobacter pylori 

        Prasad, Yedu
        Helicobacter pylori is the leading cause of gastric cancer in human beings. It is a helix-shaped, Gram-negative, motile bacteria that colonizes the gastric mucosa and eventually the gastric epithelium. It has an overabundance ...
      • Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery 

        Anand, Praveen (2018-08-13)
        BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large ...
      • A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals 

        kumari, Nitu
        The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...
      • Light-And Cytokinin-Regulated Plastid And Nuclear Gene Expression In Cucumber (Cucumis Sativus L) 

        Ullanat, Rajesh (Indian Institute of Science, 2005-12-06)
        Light and phytohormones, such as cytokinins, have been known to play a pivotal role in numerous physiological processes in plant cells. Previous work in our laboratory has revealed the light- and cytokinin- modulated changes ...

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