Browsing Biochemistry (BC) by Title
Now showing items 86-105 of 250
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Immunochemical Studies on the family of Biotin Binding Proteins
(Indian Institute of Science, 2005-04-29)Investigations detailed in this thesis constitue a part of continuing programme of research work undertaken in this laboratory on vitamin binding proteins. Avidin from the chicken egg white, streptavidin &om the bacterium ... -
Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection
(2018-06-15)Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ... -
Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality
Immunomodulation is a process by which the immune response of the host is either enhanced or suppressed due to various factors which either protects or makes the host more susceptible to particular diseases. Immunomodulators ... -
Immunoneutralization Of Cytotoxic Abrin : Insights Into Mechanisms And Therapy
(2015-12-02)Type II Ribosome Inactivating Proteins (RIPs), commonly known as A/B toxins are heterodimers comprising of a catalytically active A chain, an RNA N-glycosidase which inhibits protein synthesis and a lectin-like B chain ... -
Implications of Soluble Diacylglycerol Acyltransferases in Triacylglycerol Biosynthesis in Yeast and Plants
(2018-04-12)Lipids are stored in a cell for providing energy. The main advantages of storing lipids over carbohydrates like glycogen is that, lipids yield more energy after oxidation because they represent the highly reduced form of ... -
In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ... -
Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule
(2018-04-24)Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a ... -
Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis
Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ... -
Insights Into Oxidative Folding Of Retinol Binding Protein In The Endoplasmic Reticulum : A Study In Isolated Microsomes
(2009-04-30)The central role played by the Endoplasmic Reticulum (ER) in the correct folding and assembly of secretary and membrane proteins cannot be overstated. As the first compartment in the secretary pathway, it is responsible ... -
Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin
Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ... -
Insights Into The Mechanism Of Polyprotein Processing Of Sesbania Mosaic Virus And Characterization Of The Polyprotein Domains
(2013-06-10)1. Viruses are obligate parasites that hijack the host cell machinery to synthesize their own gene products and for their propagation. In order to establish a successful viral infection, viruses have evolved different ... -
Insights Into The Trans-Splicing Based Expression Of Heat Shock Protein 90 In Giardia Lamblia
(2016-09-14)Heat shock proteins (Hsps) are a class of molecular chaperones which were first discovered as proteins up-regulated in response to heat stress in Drosophila. Later, it was found that these set of proteins get up-regulated ... -
Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
(2014-12-01)Introduction Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ... -
Invertase in a thermophilic fungus, thermomyces lanuginosus: its unusual behaviour And regulation
(Indian Institute of Science, 2005-04-25)The understanding of the phenomenon of thermophily requires investigations of both thermophilic prokaryotes and eukaryotes. In the eukaryotes, thermophily is exhibited only by a few species of fungi which can grow up to ... -
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...