Browsing Biochemistry (BC) by Title
Now showing items 191-210 of 409
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Modulation of HMGCoA reductase activity by adenine nucleatides, iron and adrimycin.
Abstract not available -
Molecular and biochemical studies on components of transcription regulation, tropane alkaloid biosynthesis and signal transduction in the medicinal plant Datura metel L.
Tropane alkaloids (TA) are among the oldest medicines known to humankind as they possess hallucinogenic and poisonous properties. Datura metel, an herbaceous plant, belongs to the family Solanaceae whose members are well ... -
Molecular Approaches To understand Cellular Differentiation - A Study Using BeWo Choriocarcinoma Cells
(2010-05-24)Cellular differentiation is a complex but fascinating process in all multicellular organisms. Differentiation can involve changes in numerous aspects of cell physiology; size, shape, polarity, metabolic activity, responsiveness ... -
Molecular Characterization of Groundnut Bud Necrosis Virus Encoded Non Structural Protein m (NSm)
(2018-01-28)Chapter 3 Groundnut Bud Necrosis Virus (GBNV) is a tripartite ambisense RNA plant virus that belongs to serogroup IV of Tospovirus genus. Non-Structural protein-m (NSm), which functions as movement protein in tospoviruses, ... -
Molecular Cloning And Characterization Of A Calcium-Depdendent Protein Kinase Isoform ScCPK1 From Swainsona Canescens
(2013-06-10)Plants are constantly exposed to pathogens and various environmental stresses, such as cold, salinity and drought. Plants normally respond rapidly to these biotic and abiotic stresses. Efficient perception of biotic and ... -
Molecular dissection of Komagataella phaffii Rtg1–RtgX function and development of a glutamate-responsive protein expression platform
In Saccharomyces cerevisiae, the basic helix-loop-helix leucine zipper (bHLH-LZ) proteins Rtg1 and Rtg3 form a heterodimeric transcription factor complex that mediates the retrograde response. In Candida albicans, these ... -
Molecular Genetic Analysis Of The Role Of Nse2, A SUMO E3 Ligase Of The Smc5/6 Complex, In Resisting Genotoxic Stress And Maintaining Chromosome Stability In Saccharomyces Cerevisiae
(2011-01-20)DNA repair pathways have evolved to protect the genome from damage caused by intrinsic and extrinsic factors. Although numerous DNA repair mechanisms have been studied and reported, information regarding how they coordinate ... -
Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ... -
Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ... -
Molecular Mechanisms Underlying Phosphatidylinositol-Specific Phospholipase C Mediated Regulation Of Lipid Metabolism
(2016-03-04)Phosphoinositide-specific phospholipase C (PLC) is involved in Ca2+ mediated signalling events that lead to altered cellular status. PLC activation causes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and ... -
Molecular mimicry by an antiidiotypic monoclonal antibody to gonadotropin releasing hormone : Binding and signalling properties
This thesis deals with the establishment and characterization of monoclonal antibodies (mAbs) to gonadotropin-releasing hormone (GnRH) receptor, with particular emphasis on the investigations into the abilities of the mAbs ... -
A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers
Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ...