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Studies of Pyridoneimine in Site-Selective Functionalization of Carbohydrates and in Multivalent Phenomenon
Carbohydrates are functionally rich biomolecules with multiple hydroxy functionalities. As a result, the most often practiced chemical route is to install protecting groups that permit selective functionalization at the ...
Enantioselective Annulation Reactions: From Fischer Indolization to de novo Arene Construction
In summary, we have developed the first decarboxylative [4+2]-annulation of ethynyl
benzoxazinanones with azlactones for the enantioselective synthesis of cyclic α-quaternary
α-acylaminoamides.25 This direct and modular ...
Unleashing the Potential of Nanomaterials in Organic Synthesis: QD-based Photocatalysis and AuNP-catalysed Cascade Rearrangement Reaction
The thesis titled Unleashing the Potential of Nanomaterials in Organic Synthesis: QD-based Photocatalysis and AuNP-catalysed Cascade Rearrangement Reaction explores innovative strategies for organic synthesis using ...
Functionalized Low-Dimensional Nanomaterials in Antibacterial Activity and Drug Delivery
The rise in multi-drug-resistant bacterial infections is a major health concern of the 21st-century. Overuse of traditional antibiotics in medical, agricultural, and veterinary practices has led to numerous drug-resistant ...
N-Heterocyclic Carbene-Catalyzed Synthesis of Oxazolones, e-Lactones and N-N Axially Chiral Molecules
The diverse reactivity of N-heterocyclic carbenes (NHCs) in organocatalysis is due to the possibility of different modes of action. Although NHC-bound enolates and dienolates were well-known, the NHC-bound cross-conjugated ...
Harnessing Strained Systems: Arynes, Donor Acceptor Cyclopropanes, and Bicyclobutanes in Annulations, Multicomponent Couplings and Insertion Reactions
More than a century ago, the discovery of aryne intermediates proved to be a valuable addition
to the toolkit of organic chemists, enabling the synthesis of a diverse range of molecules using these
electrophilic ...
N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Dihydrothiopyranones, Functionalized Benzofurans and Extending Michael Acceptor Aldimine Umpolung
Carbenes exhibit high reactivity as divalent species with six electrons in their valence shell. Their
electrophilic nature arises from an incomplete octet. However, when a heteroatom is introduced adjacent
to the carbene ...
Lanthanide-derived Photoluminescent Hydrogels for Analytical Screening of Norfloxacin, Ofloxacin, α-Chymotrypsin, and Gossypol
Supramolecular gels are soft substances made of elastic cross-linked three-dimensional network connected by noncovalent interactions such as hydrogen bonds, hydrophobic interactions, donor-acceptor interactions, π- π ...
HBS Constrained Antiparallel β-Sheets and Flat Toroid Turns; Homoserine, Thioamide and 1,3-Thiazine Containing Peptidomimetics: Design, Synthesis, Conformational Analyses and applications
In chemical biology, short peptidomimetic biological active models have been widely used for anti-microbial activity, drug development, catalysis, and amyloidogenesis. In this thesis, I have synthesized several unnaturally ...
Engineering of Nanomaterials: Application in Antibacterial Activity, Bio-Analyte Detection and Environmental Remediation
Infectious diseases caused by pathogenic bacteria are creating a global health problem. In the recent report of World Health Organization (WHO), it has been mentioned that around 7 lacks people are dying each year worldwide ...