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Now showing items 6291-6310 of 6415
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Unravelling The Mechanisms Of Myofibrillogenesis And Human Myopathies Using Drosophila Mutants
(2013-07-18)Myofibrillogenesis is a complex process, which involves assembly of hundreds of structural proteins in a highly ordered manner to form the contractile structural unit of muscle, the sarcomere. Several myopathic conditions ... -
Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis
(2018-07-20)The thesis entitled “Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis" consists of five chapters. A basic introductory section describes the topics relevant to the work ... -
Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus
(2013-06-07)Unravelling the regulators of translation and replication of Hepatitis C virus Hepatitis C virus (HCV) is a positive sense, single stranded RNA virus belonging to the genus Hepacivirus and the family Flaviviridae. It ... -
Unsteady Flow Field Downstream Of A Sudden Expansion
(2009-04-02)Separating and reattaching flows are important in a large number of engineering configurations. The flow through a sudden expansion (backward-facing step) represents a conceptually simple case of this class of flows and hence ... -
Unsteady Two Dimensional Jet with Flexible Flaps at the Exit
(2017-11-13)The present thesis involves the study of introducing passive exit flexibility in a two dimensional starting jet. This is relevant to various biological flows like propulsion of aquatic creatures (jellyfish, squid etc.) and ... -
Untangling the Helicobacter pylori genome: Deciphering the significance of zinc finger motif(s) in Topoisomerase I catalysis
Helicobacter pylori, a human pathogen dominating gastric microbial population, displays differential gene expression during various stages of stomach colonization. Topoisomerases play a crucial role in maintaining DNA ... -
Unusual Acylation Properties Of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins
(2010-07-06)This thesis entitled ‘ Unusual Acylation Properties of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins’ describes the discovery of self-acylation and malonyl transferase activity in acyl carrier proteins involved in ... -
Upper Bound Finite Element Limit Analysis for Problems of Reinforced Earth, Unsupported Tunnels and a Group of Anchors
(2017-11-27)This thesis presents the implementation of the upper bound limit analysis in combination with finite elements and linear optimization for solving different stability problems in geomechanics under plane strain conditions. ... -
Upper Frequency Bound on Circuit-Based Models for Transformer Windings
The power generation, transmission and utilisation are necessarily being carried out at different voltage levels, and require transformers for performing the voltage level conversions. As a result, transformers form one ... -
Urbanisation and Shifting Phenotypes Behavioural, Physiological and Cognitive Strategies of the Indian Rock Agama Psammophilus Dorsalis
(2018-07-09)Humans directly or indirectly cause changes in the environment, and urbanisation is currently one of the most important threats to biodiversity. Urbanisation exposes organisms to novel pressures that are drastically different ... -
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach Epilepsies are a group of neurological disorders with a prevalence of 70 million people worldwide ... -
Use of Human Induced Pluripotent Stem Cells as a Model to Study Primary Microcephaly
The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ... -
Use of strategically designed protein-like sequences in structure and function recognition
The advent of high fidelity protein sequencing techniques has led to a considerable wealth of sequence data. However, the number of proteins with information on 3-D structure and functional features available is considerably ... -
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial and temporal ... -
Using Explicit State Space Enumeration For Specification Based Regression Testing
(2010-07-08)Regression testing of an evolving software system may involve significant challenges. While, there would be a requirement of maximising the probability of finding out if the latest changes to the system has broken some ...