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Now showing items 6206-6225 of 6420
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Understanding DNA-Based Nanostructures using Molecular Simulation
(2018-05-14)Deoxyribonucleic acid (DNA) is arguably the most studied and most important biological molecule. Recently, it has also been established as a potential candidate for nanoconstruction. Self-assembly of DNA molecules has ... -
Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing
(2017-11-29)Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ... -
Understanding Global Team Effectiveness In The Context Of Product Development
(2013-06-04)Today's global economy requires many organizations to co-ordinate work across a variety of intra and inter-organizational boundaries (Armstrong & Cole, 1995; Lipnack & Stamps, 1997). Global competition, re-engineered product ... -
Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases
(2013-04-04)Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ... -
Understanding High Speed Mixing Layers with LES and Evolution of Urans Modeling
(2017-11-15)This thesis is concerned with studies on spatially developing high speed mixing layers with twin objectives: (a) to provide enhanced and detailed understanding of spatial development of two-dimensional mixing layer emanating ... -
Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression
(2018-01-28)Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ... -
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ... -
Understanding Knowledge Needs And Processes In Design
(2011-01-31)In this knowledge economy, organizations are leveraging their competence through the knowledge they possess. Managing knowledge will potentially retain the competence held by the organization if knowledge generated across ... -
Understanding mRNA fate regulation by RGG motif protein, Sbp1
Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ... -
Understanding Multi-Wavelength Signatures of Galactic Outflows Through 3-D Simulations
Evolution of galaxies is a phenomenon that affects the formation and composition of galaxies, and the intergalactic medium. It is mediated by processes that establish a symbiotic relationship between a galaxy and the ... -
Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation
This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ... -
Understanding Nucleic Acid Charge Transport Properties using Multiscale Modelling Techniques
Understanding charge transport in molecular systems is of fundamental interest in rapidly growing field of molecular electronics as well as to understand biological signal transfer processes which are accompanied by the ... -
Understanding Patterns of Bird Species Distribution in the Western Ghats
(2018-06-23)Macroecology is the study of relationships between organisms and the environment at large spatial and temporal scales. This field of research examines patterns in species abundance, distribution and diversity. Understanding ... -
Understanding Phage MU Mom Regulation and Function
(2018-06-11)Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ... -
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ... -
Understanding quantitative process physics of 3D binderjet printing with validation in Ti-6Al-4V and inkjet bioprinting of mammalian cells
In the field of additive manufacturing, laser or electron beam based 3D printing is widely investigated for biomedical applications. However, much less explored is the binderjet 3D printing, which allows processing of ... -
Understanding Rules of Assembly and Species Interactions in Mixed-species Bird Flocks
In mixed-species bird flocks (flocks hereafter), participants vary in their degree of similarity with each other. Flock participants can gain group size (supplementary) benefits by choosing similar flock partners, or ... -
Understanding Solvent Effect On Triplet State Structure Of Thioxanthone And Its Derivatives Using Time-Resolved Resonance Raman Spectroscopy
(2014-05-01)It has long been recognized that course and efficiency of a chemical reaction is largely mediated by the short-lived transient species (excited state or radicals) which are formed as reactive intermediates during a chemical ... -
Understanding spontaneous emission in the strong coupling regime of an emitter and absorbing matter
This thesis proposes a partition of optical states into radiative and non-radiative parts when an emitter is proximal to resonant absorbing nanostructures. The conventional partition is valid only for the weak coupling ... -
Understanding Structure And Growth Of Physisorbed Films : A Combined Atomic Force Microscopy And Modeling Study
(2014-10-16)Surface modification has wide ranging implications in lubrication, microelectromechanical systems (MEMS), colloidal systems and biological membranes. Surface modification plays an important role in stabilizing gold ...