Browsing by Title
Now showing items 6197-6216 of 6420
-
Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease
(2018-09-04)Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in ... -
Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter
The mitochondrion is a double membrane-bound organelle found in all eukaryotic organisms. Mitochondria are endosymbiotic, autogenous organelles referred to as “Powerhouse” of cells due to their ability to synthesize ATP ... -
Understanding And Supporting Conceptual Design Synthesis Of Multiple State Mechanical Devices
(2015-08-07)Conceptual design synthesis is part of the conceptual phase of the design process, which focuses on creating alternative, candidate solutions. Conceptual design phase has the greatest influence on the cost and characteristics ... -
Understanding Catchment Scale Processes: Hydrological Modelling and Information-Theoretic Approaches
Catchments are complex environmental systems, and they serve as the fundamental units for hydrological classification. They are self-organizing systems whose form, drainage network, ground and channel slopes, channel ... -
Understanding cholesterol homeostasis and its impact on GPCR signalling in aging
Full text embargo One year up to July 2024 Aging is defined as the time-related deterioration of physiological functions necessary for survival of organisms. Despite significant progress in the extension of human lifespan ... -
Understanding Conformal Field Theory in Mellin Space
In the last decade, there has been tremendous progress in understanding conformal eld theories in more than two space-time dimensions. The numerical bootstrap framework has been pushed to a very advanced level of ... -
Understanding Context In Designing
(2009-05-25)Everything around us that is not a simple untouched piece of nature has been designed by someone. Human society has found a great refuge in these designed objects or the artefacts, and thus has adapted vociferously to their ... -
Understanding deformation mechanisms in the Hall-Petch breakdown regime of Ni-W alloys
The substantially higher strengths of nanocrystalline metals has been to attributed to the well-known Hall-Petch relationship σ= σ_o+k_HP d^(-1/2) where 𝜎 is the yield stress, 𝜎𝑜 is the lattice friction stress, 𝑑 is ... -
Understanding design communication in internet-enabled remote synchronous collaborative design in the early stages of design
Remote synchronous collaborative design necessitates designers to carry out the design process using web-based real-time communication applications for collaboration with co-designers. Design communication involves exchanging ... -
Understanding DNA-Based Nanostructures using Molecular Simulation
(2018-05-14)Deoxyribonucleic acid (DNA) is arguably the most studied and most important biological molecule. Recently, it has also been established as a potential candidate for nanoconstruction. Self-assembly of DNA molecules has ... -
Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing
(2017-11-29)Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ... -
Understanding Global Team Effectiveness In The Context Of Product Development
(2013-06-04)Today's global economy requires many organizations to co-ordinate work across a variety of intra and inter-organizational boundaries (Armstrong & Cole, 1995; Lipnack & Stamps, 1997). Global competition, re-engineered product ... -
Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases
(2013-04-04)Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ... -
Understanding High Speed Mixing Layers with LES and Evolution of Urans Modeling
(2017-11-15)This thesis is concerned with studies on spatially developing high speed mixing layers with twin objectives: (a) to provide enhanced and detailed understanding of spatial development of two-dimensional mixing layer emanating ... -
Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression
(2018-01-28)Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ... -
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ... -
Understanding Knowledge Needs And Processes In Design
(2011-01-31)In this knowledge economy, organizations are leveraging their competence through the knowledge they possess. Managing knowledge will potentially retain the competence held by the organization if knowledge generated across ... -
Understanding mRNA fate regulation by RGG motif protein, Sbp1
Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ... -
Understanding Multi-Wavelength Signatures of Galactic Outflows Through 3-D Simulations
Evolution of galaxies is a phenomenon that affects the formation and composition of galaxies, and the intergalactic medium. It is mediated by processes that establish a symbiotic relationship between a galaxy and the ... -
Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation
This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ...