Browsing by Title
Now showing items 5281-5300 of 6421
-
Structure, Stability and Evolution of Multi-Domain Proteins
(2018-04-11)Analyses of protein sequences from diverse genomes have revealed the ubiquitous nature of multi-domain proteins. They form up to 70% of proteomes of most eukaryotic organisms. Yet, our understanding of protein structure, ... -
Structure, Stability And Interfacial Studies Of Self Assembled Monolayers On Gold And Silver Surfaces
(2009-07-30)Nanostructured materials play a vital role in almost all aspects of science and technology in the 21st century. The materials include nanoparticles, nanofilms, biological membranes etc. whose physicochemical properties are ... -
Structure, Thermodynamics and Dynamics in Complex Systems: From Stability of Biomolecules to Phase Transitions in Polymorphic Ice
This thesis deals with the understanding of the structure, dynamics and thermodynamics in complex systems (proteins, hydration layers, DNA, ice polymorphs) by employing computer simulations, theoretical analysis, and in ... -
Structure- Function Studies on Triosephosphate Isomerase : Some Old Questions, Some New Insights
This thesis describes biophysical, kinetic, structural, and sequence conservation analysis of the glycolytic enzyme triosephosphate isomerase (TIM). TIM catalyses the diffusion limited isomerization of D-glyceraldehyde-3-phospahte ... -
Structure-Activity Correlation and Mechanistic Investigations of Glutathione Peroxidase-Like Catalytic Activity of Diaryl Diselenides
Hydroperoxides are very harmful and they can oxidize several biomolecules, causing different disease states. Glutathione peroxidase (GPx) is a mammalian selenoenzyme which protects human body from oxidative damage by ... -
Structure-Function Analysis of Focal Adhesion Protein Vinculin in Neocortical Axon Growth and Development
Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ... -
Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis
Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ... -
Structure-Function Control in Organic Co-Crystals/Salts Via Studies on Polymorphism, Phase Transitions and Stoichiometric Variants
(2018-06-19)The thesis entitled “Structure-function control in organic co-crystals/salts via studies on polymorphism, phase transitions and stoichiometric variants” consists of five chapters. The main emphasis of the thesis is on ... -
Structure-Function Correlations In Aminoacyl tRNA Synthetases Through The Dynamics Of Structure Network
(2010-08-16)Aminoacyl-tRNA synthetases (aaRSs) are at the center of the question of the origin of life and are essential proteins found in all living organisms. AARSs arose early in evolution to interpret genetic code and are believed ... -
Structure-Function Correlative Studies On The Biochemical Properties (Polymerisation, GTP binding, GTPase) Of Mycobacterial Cytokinetic Protein FtsZ In Vitro
(2010-03-26)FtsZ, the principal cell-division protein, polymerizes in GTP-dependent manner in vitro (Bramhill and Thompson, 1994; Mukherjee and Lutkenhaus, 1994; Rivas et al., 2000). FtsZ polymerization at the mid-cell site of bacterium ... -
Structure-Function Relationships of Saccharomyces Cerevisiae Meiosis Specific Hop 1 Protein : Implications for Chromosome Condensation, Pairing and Spore Formation
(2018-03-07)Meiosis is a specialized type of cell division essential for the production of four normal haploid gametes. In early prophase I of meiosis, the intimate synapsis between homologous chromosomes, and the formation of chiasmata, ... -
Structure-Function Studies On Triosephoshate Isomerase From Plasmodium falciparum And Methanocaldococcus jannaschii
(2010-08-16)This thesis describes studies directed towards understanding structure-function relationships of triosephosphate isomerase (TIM), from a protozoan parasite Plasmodium falciparum and a thermophilic archaea Methanocaldococcus ... -
Structure-Property Correlation in Additively Manufactured High-Temperature Materials: Insights from Nickel-Based Superalloy IN718 & Nickel-Based Eutectic High Entropy Alloy AlCoCrFeNi2.1
High-temperature alloys are technically very important materials that possess higher resistance toward mechanical and chemical degradation at 0.4-0.6 TM for a constant/cyclic load. These attributes make them candidate ... -
Structure-Property Correlation in Binary Immiscible Polymer Blends Compatibilized by Mutually Miscible Homopolymer and Carbonaceous Nanoparticles
The thesis systematically studies the various morphology, mechanical properties, crystallization kinetics and compatibilization effects of homopolymers, carbonaceous nanoparticles such as multiwall carbon nanotubes (MWNTs), ... -
Structure-Property correlation in epoxy composites containing carbonaceous nanoparticles
Epoxy is widely used as thermosetting materials in carbon fiber composites due to its combined superior thermal and mechanical properties which makes them a potential candidate for myriad applications. But epoxy suffers ...