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Plasticity of Intrinsic Excitability in Fast Spiking Interneurons of the Dentate Gyrus & Its Implications for Neuronal Network Dynamics
Inhibitory GABAergic neurons, although forming a minor proportion of the neuronal population in the central nervous system, have been reported to be crucial for different physiological states of the brain. Among the vast ...
Role of Lactate and TREK1 Channels in Neuroprotection during Cerebral Ischemia – in Vitro Study in Rat Hippocampus
(2017-12-16)
Cerebral ischemia is a highly debilitating condition where shortage of oxygen and glucose leads to profuse cell death. Insufficient blood supply to the brain leads to cerebral ischemia and increase in extracellular lactate ...
Effect of Ultrasound on Neuronal Network Communication
(2018-05-22)
Low intensity and low frequency ultrasound has been shown to modulate ion channel currents, membrane capacitive currents, and as a result, neuronal activity. Ultrasound has been used as a non-invasive way to modulate ...
Ischemic Concentrations of Lactate Increase TREK1 Channel Activity and Expression
TREK1 is a two-pore domain leak potassium channel which contributes to resting membrane
potential. TREK1-/- mice exhibit increased neuronal mortality after global ischemia. Neuroprotective agents like volatile anesthetics ...
Pharmacological Modulation Of Recombinant Human Two-Pore Domain K+ Channels : Whole-Cell patch-Clamp Analysis
(2011-10-21)
Background potassium currents play an important role in the regulation of the resting membrane potential and excitability of mammalian neurons. Recently cloned two- pore domain potassium channels (K2p) are believed to ...
Intracellular Calcium Dynamics In Dendrites Of Hippocampal Neurons Rendered Epileptic And In Processes Of Astrocytes Following Glutamate Pretreatment
(2009-04-03)
The fundamental attribute of neurons is their cellular electrical excitability, which is based on the expression of a plethora of ligand- and voltage-gated membrane channels that give rise to prominent membrane currents ...
Protein-small molecule interactions: Structural insights and applications in computational drug discovery
Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the ...
Integrative modeling of NS3 helicase function with molecular kinetics, molecular simulations and machine learning
The viral NS3 helicase is a crucial enzyme involved in the RNA replication of positive strand ssRNA viruses of the Flaviviridae family. The NS3 is an active motor that binds RNA and couples ATP hydrolysis to the mechanical ...
Development of quantitative RNA sequencing methods to understand RNA variant diversity.
The advent of next-generation sequencing (NGS) has accelerated biological research by providing the opportunity to connect genome level sequence information to function. One key application of NGS has been analysis of gene ...