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A systems-level exploration of host responses across the disease spectrum of Tuberculosis and COVID-19
The host immune system orchestrates a defense mechanism against any invading pathogen with a combination of many mechanisms including antibody production, T-cell response, and memory response. The manner and extent of host ...
Roles of Drosophila Beadex and CG9650 in the development and functioning of the larval neuromuscular junctions
In eukaryotes, all voluntary and involuntary actions like, cognition, learning & memory, voluntary
movements, feeding, etc., are coordinated by the employment of neuronal circuitry that transmits
the signal from the ...
First thorough characterization of the structure, interactions and specificity of an archeal lectin with implication for TB infection
Decades long studies on plant lectins carried out in this laboratory have contributed substantially to glycobiology and helped in the initiation and development of macromolecular crystallography in India. Subsequently the ...
Solution structures and interaction studies of mycobacterial MazEF6 toxin-antitoxin system
Toxin-Antitoxin (TA) systems are stress response systems found on plasmids and chromosomes
of bacteria and archaea. They are involved in important functions such as
plasmid maintenance, programmed cell death, persister ...
Evaluation of Early Pathogenic Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
(2017-12-07)
Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder in the elderly, characterized by severe loss of memory and higher cognitive functions. In the hundred years since its discovery, Alzheimer’s ...
Dynamics of Invariant Object Representations in the Monkey Inferotemporal Cortex
(2018-06-18)
Vision is computationally challenging because objects in the real world can change in size, position, viewpoint etc., and therefore cast a myriad images on the retina. Viewpoint changes are particularly challenging because ...
The Role of Cytoskeletal Morphology in the Nanoorganization of Synapse
(2018-01-10)
Synapse is the fundamental unit of synaptic transmission. Learning, memory and neurodegenerative diseases of the brain are attributed to the maintenance and alteration in synaptic connections. The efficiency for synaptic ...
Structural and Functional Analysis of Proteins involved in Microbial Stress Tolerance and Virulence
(2018-08-11)
The genus Salmonella consists of pathogenic gram negative organisms which infect intestines of birds, animals and humans. They are the causative agents of salmonellosis which is characterised by diarrhoea, nausea, fever ...
Mechanisms of Dopaminergic Neurodegeneration in Parkinson's Disease
(2018-07-18)
Parkinson’s disease (PD) is a debilitating movement disorder. The cardinal symptoms of PD are bradykinesia, resting tremors and rigidity. PD is characterized by degeneration of dopaminergic neurons of A9 region, substantia ...
Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells
(2018-08-11)
RAGs (Recombination Activating Genes) are responsible for generation of antigen receptor diversity in case of B-cells and T-cells, through the process of combinatorial joining of different V (variable), D (diversity) and ...