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Now showing items 1011-1018 of 1018
Elucidating the Role of miR-617 in Oral Squamous Cell Carcinoma Pathogenesis
Oral Squamous Cell Carcinoma (OSCC) or oral cancer is the malignancy of the epithelial lining
of the oral cavity. It is the leading cause of cancer-related mortality in Indian males and despite
technological advancements, ...
Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling
(2015-08-19)
Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ...
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an
organism. Dysregulation in the process of wound healing leads to the production of excess
extracellular matrix leading to fibrosis. ...
Understanding the interaction mechanism of bacterial virulence factors and effector proteins with host lipid membrane using single particle cryo-electron microscopy
Pathogenic bacteria employ an array of biological macromolecules and cellular
structures that help in the initiation and progression of disease in host organism.
These ‘virulence factors’ can either be secreted by the ...
Venomics of Medically Important yet Neglected Elapid Snakes of India and the Antivenomic Potential of Plant Extracts
India is considered the world's snakebite capital, where over 58,000 snakebite fatalities are registered annually. Most bites are primarily attributed to four snake species: the spectacled cobra (Naja naja), common krait ...
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ...
Astroglial development as the basis for the effects of early life stress on adult depressive-like behavior
This thesis investigates the enduring effects of early-life stress, specifically maternal separation, on astroglial population and the subsequent behavioral outcomes in adult mice. While the persistent impact of early-life ...