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Genetics of Glioblastoma: Insights into Biology and Therapy Resistance
The central nervous system contains the neural stem cells which differentiate and give rise to the neurons as well as the glial cells which are non-neuronal in nature and provide support and protection to neurons. Unlike ...
A place for everything and everything in its place: Spatial organization of wasps on the nests of the primitively eusocial paper wasp Ropalidia marginata
In my thesis, I found that queens and workers in the primitively eusocial paper wasp Ropalidia marginata use space on their nests non-randomly with a majority of individuals showing spatial fidelity to small core areas, ...
Soil microorganisms and biogeochemical cycles in a grazing ecosystem: interactions between producers, consumers, and decomposers
Microorganisms are the unseen majority that determines ecosystem processes, they perform
biogeochemical functions that translate into essential services, and regulate global climate. In
grazing ecosystems, which represent ...
Role of SIRT6 in the Regulation of Glucose Metabolism and Fatty Acid Uptake in Heart
The adult heart heavily relies on fatty acid for most of its energy supplies. The heart derives most of the fatty acid from circulation. Hence, fatty acid uptake forms a crucial step in cardiac metabolism. Studies have ...
Climate-Growth Relationships of West Himalayan Fir (Abies pindrow) along an Altitudinal Gradient in Northwestern Himalaya
Climate change which includes an increase in temperature, changes in precipitation, retreating of glaciers, has a significant impact on ecosystem dynamics and the social communities. High mountains around the globe are ...
Regulation of Hepatitis C Virus life-cycle by lncRNA HULC: crosstalk with other host factors
Hepatitis C virus (HCV) is a positive sense single-stranded RNA virus. It belongs to the family Flaviviridae and the genus hepacivirus. Following the receptor-mediated endocytosis, HCV genome is released into the cytoplasm, ...
Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria
The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ...
Biochemical, Genetic and Molecular characterization of TCP3 and TCP4 transcription factors in Arabidopsis thaliana
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) family of proteins consists of plant-specific, non-canonical basic helix-loop-helix transcription factors that perform diverse developmental processes. ...
Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ...