etd AT Indian Institute of Science: Recent submissions
Now showing items 3181-3200 of 8210
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Design and Development of Novel Fiber Bragg Grating based devices for various Biomedical applications
Sensors have always been an integral part of human life. Apart from the numerous inherent sensors which the human body possesses, there are various man-made sensors which has been studied and implemented widely to fulfill ... -
Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli
The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ... -
Electrochemical and Spectroscopic Investigations of Some Redox Active Biomolecules
The thesis attempts to ask a few questions related to heme electrochemistry and provide possible answers to these in terms of experimental results obtained and reported in the current literature. It is expected that the ... -
Microstructure, mechanical behavior, and thermal stability of in-situ polymer-derived ceramic reinforced Al-based composites
Al-based metal matrix composites (MMCs) show a high strength-to-weight ratio which makes them attractive for the aerospace and automobile industries. The reinforcements for the same have conventionally been micron-sized ... -
Shape-constrained Biomedical Image Segmentation and Applications
The detection, segmentation, and delineation of the targeted regions of interest in biomedical images are fundamental steps for computer-aided assessment and prescreening. In this thesis, we focus on shape-constrained ... -
Synergetic effect of electrostatic gating and interfacial states in molecular switching operation in molybdenum disulfide based thin hetero-interfaces
Nowadays, two-dimensional (2D) materials have stimulated intensive research due to their intriguing physical properties and excellent electronic application. van der Waals (vdW) semiconductors are attractive for electrically ... -
Ethylene Glycol in the Liquid State: Structure, Conformation and Dynamics - A Study Using Ab Initio Molecular Dynamics Simulations
Ethylene glycol (EG) is an important organic molecule with unique properties and a wide range of applications. The EG molecule shares a structural motif with many biomolecules and serves as a part of the training set for ... -
Solution structures and conformational isomerism of novel conopeptides from Indian marine cone snails
This thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, ... -
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology
Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ... -
Studies on Soluble Lead Redox Flow Battery
Redox flow batteries (RFBs) offer an opportunity to make renewable energy storage more affordable and could accelerate prospects for utility-scale development of solar/wind energy storage. RFBs can be almost instantly ... -
Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ... -
Territorial and mating strategies of males in a lekking population of blackbuck Antilope cervicapra
Territoriality associated with lek-mating systems is unique in that males defend small, heavily clustered territories that lack resources usually thought to attract females, such as food and water. Females visit these male ... -
Representations of Special Compact Linear Groups of Order Two : Construction, Representation Growth, Group Algebras and Branching Laws
Let o be the ring of integers of a non-Archimedean local field such that the residue field has characteristic p: Let p be the maximal ideal of o: For Char¹oº = 0; let e be the ramification index of o: i.e., 2o = pe: Let ... -
A Phylogenetic Perspective on The Phytogeography of Western Ghats
I used a finer scale data of 156 published plots across the entire latitudinal range of WG, covering most of the protected forests. The pruned phylogeny for this study consisted of 367 species, of which ~ 50% are taxa endemic ... -
CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ... -
Multiscale Modeling of Quantum Transport in 2D Material Based MoS Transistors
Atomically thin 2D materials have ushered in a new era in the fi eld of nano-science and tech- nology and have been translated to notable advancements in the design of sensors, optoelectronic devices, exible electronics. ... -
Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation
In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ... -
Microstructure and texture evolution in wire drawing and its role on the tension and torsion response of nickel microwires
It is now well known that the strength of the metallic materials depends on microstructural features such as dislocation density, grain size, and precipitates. The migration of lattice defects such as dislocations is a ...