etd AT Indian Institute of Science: Recent submissions
Now showing items 3161-3180 of 8174
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CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ... -
Multiscale Modeling of Quantum Transport in 2D Material Based MoS Transistors
Atomically thin 2D materials have ushered in a new era in the fi eld of nano-science and tech- nology and have been translated to notable advancements in the design of sensors, optoelectronic devices, exible electronics. ... -
Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation
In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ... -
Microstructure and texture evolution in wire drawing and its role on the tension and torsion response of nickel microwires
It is now well known that the strength of the metallic materials depends on microstructural features such as dislocation density, grain size, and precipitates. The migration of lattice defects such as dislocations is a ... -
Experiences in using Reinforcement Learning for Directed Fuzzing
Directed testing is a technique to analyze user-specified target locations in the program. It reduces the time and effort of developers by excluding irrelevant parts of the program from testing and focusing on reaching ... -
Achieving Fairness in the Stochastic Multi-Armed Bandit Problem
The classical Stochastic Multi-armed Bandit (MAB) problem provides an abstraction for many real-world decision making problems such as sponsored-search auctions, crowd-sourcing, wireless communication, etc. In this work, ... -
Some results on Spectral spaces and Spectral sequences
This thesis is made up of two independent parts. We begin the first part by showing that the collection of all prime ideals of a monoid or, in other words, the spectrum of a commutative monoid, endowed with the Zariski ... -
Interactions between host cellular factors and Rotaviral viroplasmic non-structural proteins NSP5, NSP2 and their influence on virus replication
Overall, the present study demonstrates the dynamic nature of rotavirus viroplasm and how it manipulates the intracellular environment by intracellular relocalization of host proteins and their sequestration in viroplasms ... -
At-site and Multisite Probabilistic Forecasting of Streamflow
Streamflow forecasts are very useful for a variety of applications such as flood warning, reservoir operation and water resources planning and management, especially in countries like India where streamflow can be highly ... -
Studies on switching of J and H aggregates in Donor-Acceptor molecular materials
The aggregation of molecular materials plays a central role in determining their functional properties. In the aggregated state, conjugated chromophores may exhibit enhanced emission, in comparison to their dilute ... -
Pathogen-derived volatiles modulate flight or fight response in Caenorhabditis elegans
In nature, the interaction between two organisms largely relies on their ability to sense and respond to each other, which involves many specific chemicals and signaling pathways. Animals have evolved mechanisms to detect ... -
Investigation of cell membrane dynamics: A potential marker for lipid response towards membrane-active proteins and peptides
The cell membrane is made up of lipids and proteins held together with intermolecular hydrophobic/hydrophilic interactions. These physical non-covalent interactions help in maintaining the integrity of the cell membrane, ... -
Studies on the synthesis and applications of I-III-VI2 semiconductor nanocrystals
Nanomaterials have been a topic of extensive research for the past several decades. This is because their properties act as a bridge between their bulk and atomic counterparts. Broadly, nanoparticles can be characterized ... -
Control of shock-induced vortex breakdown in Transonic regime on a slender delta wing body configuration using blowing
Modern high speed aircrafts feature highly swept and low aspect ratio wings, mainly to increase the critical Mach number and reduce the wave drag. A special case of swept wings is wings with triangular planform commonly ... -
A Study of the Low-Energy Spectrum and Phase Structure of a Yang-Mills Matrix Model
Yang-Mills theory is a non-Abelian gauge theory based on the gauge group SU(N), and lies at the heart of the QCD, the theory underlying strong interactions. Due to the fundamental property of asymptotic freedom, a study ... -
Modeling, Analysis and Control of Reconfigurable Battery/Grid Tied Solar Photo-Voltaic Inverter
Grid reliability and power outages are key concerns today, due to the ever-increasing energy demand. Traditionally, Uninterruptible Power Supplies (UPS) with battery storage have been employed to contend with grid outages. ... -
Fuel Drop Splashing on Heated Solid Surfaces
Droplet-wall interactions on heated surfaces are significantly encountered in applications such as fuel spray impingement in combustors and spray cooling. The present thesis is focused on the splashing of fuel drops on ... -
Electrochemical Behavior of Metallic Coatings Containing Carbonaceous Additives
Coatings have been traditionally used for protection against corrosion. Therefore, substantial efforts have been focused on engineering the microstructure and morphology of coatings to enhance their corrosion resistance ... -
Mechanical Reliability of Metal-Si Systems at different Length scales under Thermal Cyclic Loading
Metal structures of nanometer to micrometer sizes in different configurations, such as thin films, thick coatings and 3D interconnects, are widely used for conducting electrical signals in several semiconductor-based ... -
Electric Field-Guided Alignment of Carbon Nanotubes in Polymer Matrix Composites for Structural Applications
Carbon nanotubes (CNTs) have been extensively researched for diverse applications in recent years. In the present work, the use of low frequency non-uniform alternating electric fields to manipulate the alignment behavior ...