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Investigations on the Possible Role of Aromatic β-Glucoside Metabolism in Self-Defense in Enterobacteriaceae
(2018-04-02)
Bacteria are ubiquitous in all ecosystems and are often challenged by multiple stresses such as extreme temperatures, high salt concentrations, nutrient limitation, pH variations, radiation, predation and the presence of ...
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
(2018-02-28)
Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ...
Biochemical And Functional Characterization Of Evolutionarily Conserved Metallophosphoesterases The 239FB/AB Family
(2010-12-30)
With the advent of large scale genome sequencing efforts along with more sophisticated methods of genetic mapping, a number of loci have been identified that are associated with human diseases. Intriguingly, many genes ...
Human Spermatogenesis : Differential Gene Expression And Regulation
(2010-08-24)
Spermatogenesis is a complex process of male germ cell development in which the diploid spermatogonia undergo series of mitotic divisions and differentiation steps culminating into the preleptotene spermatocytes which then ...
Activation Of Glycoprotein Hormone Receptors : Role Of Different Receptor Domains In Hormone Binding And Signaling
(2014-07-16)
The glycoprotein hormones, Luteinizing Hormone (LH), human Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) are heterodimeric proteins with an identical α-subunit ...
Functional Analysis Of Primary Microcephaly Gene Product ASPM
(2013-06-20)
Autosomal recessive primary microcephaly (MCPH) is defined by congenital microcephaly and associated mental retardation with head circumference of the affected individual at least 3 standard deviations below age- and ...
Metallophosphoesterases In Mycobacteria Enigmatic Roles In Regulating Mycobacterial Physiology
(2014-04-29)
Pathogenic bacteria such as M.tuberculosis have evolved several mechanisms to aid their intracellular survival and subvert host defenses. One of the contributing factors is thought to be the production and secretion of ...
Studies On Molecular Analysis Of Capacitation Associated Protein Tyrosine Phosphorylation In Hamster Spermatozoa
(2014-04-07)
In mammals, freshly ejaculated spermatozoa do not possess the ability to fertilize a mature oocyte. They acquire fertilization competence upon residing for a period of time in the female reproductive tract. The physiological ...
Unravelling The Mechanisms Of Myofibrillogenesis And Human Myopathies Using Drosophila Mutants
(2013-07-18)
Myofibrillogenesis is a complex process, which involves assembly of hundreds of structural proteins in a highly ordered manner to form the contractile structural unit of muscle, the sarcomere. Several myopathic conditions ...