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    Design, Biophysical Characterization, and Serum Epitope Mapping of SARS-CoV-2 RBD Vaccine Immunogens 

    Kanjo, Kawkab
    Embargo up to Jan 9, 2026

    Deep Mutational Scanning Analyses of Protein Stability and Function 

    Kohli, Pehu
    Full text Embargo up to Sep 2026 Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable ...
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    Enhancing Therapeutic Potential of Antimicrobial Peptides by Tuning Backbone Conformation 

    Priyadarshini, Swati
    Full text embargo up to Dec 31, 2026 The work reported in this thesis involves tuning the backbone conformation of b-hairpin AMPs to reduce their cytotoxicity, which is determined in terms of reduced hemolytic activity, ...

    Design of viral entry inhibitors and vaccines 

    Chakraborty, Debajyoti
    Full text Embargo upto 12/12/2026 Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global health threats, despite significant efforts in the development of vaccines and major strides in ...
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    Immunogen design to enhance Influenza and SARS-CoV-2 vaccine efficacy 

    Mittal, Nidhi
    Influenza and SARS-CoV-2 are pleomorphic viruses that cause respiratory diseases in humans and present significant public health threats. Vaccination has been essential in controlling the spread of these infections and ...
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    Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics 

    Raj, Nishant
    Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ...
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    Structural Insights of Inter-domain Interactions in Multi-domain Proteins 

    Das, Sidhanta Swayam Prakash
    Embargo up to August 11, 2026. Proteins are essential biomolecules whose diverse functions stem from their modular architecture built from independently folding units called domains. This thesis investigates the nature and ...

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    AuthorChakraborty, Debajyoti (1)Das, Sidhanta Swayam Prakash (1)Kanjo, Kawkab (1)Kohli, Pehu (1)Mittal, Nidhi (1)Priyadarshini, Swati (1)Raj, Nishant (1)SubjectNATURAL SCIENCES (6)Deep mutational scanning (2)Protein folding (2)SARS-CoV-2 (2)Adjuvant (1)Antimicrobial Peptide (1)antimicrobial resistance (1)antiretroviral therapy (1)arginine residues (1)b-hairpin AMP (1)... View MoreHas File(s)
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    etd@IISc is a joint service of SERC & J R D Tata Memorial (JRDTML) Library || Powered by DSpace software || DuraSpace
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