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Design, Biophysical Characterization, and Serum Epitope Mapping of SARS-CoV-2 RBD Vaccine Immunogens
Embargo up to Jan 9, 2026
Deep Mutational Scanning Analyses of Protein Stability and Function
Full text Embargo up to Sep 2026
Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable ...
Enhancing Therapeutic Potential of Antimicrobial Peptides by Tuning Backbone Conformation
Full text embargo up to Dec 31, 2026
The work reported in this thesis involves tuning the backbone conformation of b-hairpin AMPs
to reduce their cytotoxicity, which is determined in terms of reduced hemolytic activity, ...
Design of viral entry inhibitors and vaccines
Full text Embargo upto 12/12/2026
Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global
health threats, despite significant efforts in the development of vaccines and major strides in ...
Immunogen design to enhance Influenza and SARS-CoV-2 vaccine efficacy
Influenza and SARS-CoV-2 are pleomorphic viruses that cause respiratory diseases in humans
and present significant public health threats. Vaccination has been essential in controlling the
spread of these infections and ...
Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026
Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ...
Structural Insights of Inter-domain Interactions in Multi-domain Proteins
Embargo up to August 11, 2026. Proteins are essential biomolecules whose diverse functions stem from their modular architecture built from independently folding units called domains. This thesis investigates the nature and ...

