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Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus
A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ...
Role of Glycosylation and Oligomerization on the Stability of Soybean Agglutinin
Carbohydrates are vital to life. In their naive form, they serve as a primary energy source for supporting life. However, in most cases carbohydrates do not exist as simple sugars in nature. Instead they occur as more ...
Integration of sequences, structures, dynamics to study functional divergence in homologous proteins and their assemblies
Functions of proteins are governed by their sequences, structures, dynamics and assembly. Modulation of these factors during evolution renders functional divergence in related proteins that have originated from the common ...
Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)
The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ...
Plasticity of Intrinsic Excitability in Fast Spiking Interneurons of the Dentate Gyrus & Its Implications for Neuronal Network Dynamics
Inhibitory GABAergic neurons, although forming a minor proportion of the neuronal population in the central nervous system, have been reported to be crucial for different physiological states of the brain. Among the vast ...
Rational Elicitation of Cold Sensitive Phenotypes
Conditional gene expression and conditional mutants provide a means to modulate the expression of specific genes and to control the activity of their protein products in vivo, so as to be able to study their effects on the ...
Structure- Function Studies on Triosephosphate Isomerase : Some Old Questions, Some New Insights
This thesis describes biophysical, kinetic, structural, and sequence conservation analysis of the glycolytic enzyme triosephosphate isomerase (TIM). TIM catalyses the diffusion limited isomerization of D-glyceraldehyde-3-phospahte ...
Synergistic Influence of Gene Architecture and Promoter Structure on Transcription in Plants : An in silico Analysis
Understanding the structural organisation of genome and insightful information of gene has helped in exploring the regulation and expression of the gene at a molecular and cellular level. In eukaryotes, the gene regulation ...
The Role of DNA Structural Features of Eukaryotic Promoter Sequences in Transcription Regulation
(2018-09-04)
Understanding the molecular structure of DNA was considered as greatest achievement in modern biology. It helped in understanding fundamental cellular processes such as replication of DNA, nature of the ...
Structural and Functional Characterisation of Small Heat Shock Protiens from Mycobacterium Marinum M
Small Heat Shock Proteins (sHSP) are ATP-independent molecular chaperones that exhibit diversity in structure, function and mode of action. They are present ubiquitously in all kingdoms of life. They function mainly by ...