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Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses
(2018-07-19)
Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface ...
Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes
(2018-07-04)
Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity with respect to the reaction catalyzed. Cellular activities depend ...
Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes
(2018-07-23)
Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among ...
In Silico Perspectives on RNA Structures Modulating Viral Gene Expression and Mechanics of tRNA Transport
(2018-07-19)
The repertoire of cellular functions mediated by Ribonucleic acid (RNA) molecules have expanded considerably during the last two decades. The role played by RNA in controlling and regulating gene expression in ...
Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides
(2018-06-23)
Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
Structural Investigations Of Sugar-Binding And Multivalency In Peanut Lectin
(2009-03-04)
Starting with the structure analysis of ConA in the 70s, the crystal structures of hundreds of different lectins and their carbohydrate complexes have been determined. Lectins, multivalent carbohydrate-binding proteins ...
Development of a Selective Cell-Permeable Protein Phosphatase 1 Inhibitor
(2018-07-10)
Selective ‘super-specific’ inhibitors of Protein Phosphatase 1 (PP1) are not available. Several natural product toxins possessing marginal selectivity between PP1 and the closely related Protein Serine/Threonine Phosphatase ...
Structure Function Relationship In Tryptophanyl tRNA Synthetase Through MD Simulations & Quantum Chemical Studies On Unusual Bonds In Biomolecules
(2010-10-21)
Biological processes are so complicated that to understand the mechanisms underlying the functioning of biomolecules it is inevitable to study them from various perspectives and with a wide range of tools. Understanding ...
Role of autophagy in reducing peripheral neuropathy and diabetic peripheral neuropathy
Peripheral neuropathy occurs when there is damage to the central or peripheral nervous system due to injury, disease, diabetes, or drug use. Endoplasmic reticulum (ER) stress is a distinct feature observed in neuropathic ...
Determinants of protein stability and function inferred from saturation mutagenesis and next-generation sequencing
Proteins play a central role in all biological processes. Despite a similar underlying composition, they exhibit immense diversity in structures and functions, a subject of great interest. The research presented in this ...