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Targeting The CD4 Biniding Site In HIV-1 Immunogen Design
(2016-11-15)
Over three decades have passed since the discovery of HIV-1, yet an AIDS vaccine remains elusive. The envelope glycoprotein of HIV-1 gp120, is the most exposed protein on the viral surface and thus serves as an important ...
Structural and Conformational Feature of RNA Duplexes
(2017-11-17)
In recent years, several interesting biological roles played by RNA have come to light. Apart from their known role in translation of genetic information from DNA to protein, they have been shown to act as enzymes as well ...
Structural Studies On Pyridoxal 5'-Phosphate Dependent Enzymes Involved In D-Amino Acid Metabolism And Acid Tolerance Reponse
(2015-08-19)
Metabolism of D-amino acids is of considerable interest due to their key importance in cellular functions. The enzymes D-serine dehydratase (DSD) and D-cysteine desulfhydrase (DCyD) are involved in the degradation of D-Ser ...
Sequence And Structural Determinants of Helices in Membrane Proteins
(2017-09-23)
Membrane proteins roughly constitute 30% of open reading frames in a genome and form 70% of current drug targets. They are classified as integral, peripheral membrane proteins and polypeptide toxins. α-helices and β -strands ...
Probing Macromolecular Reactions At Reduced Dimensionality : Mapping Of Sequence Specific And Non-Specific Protein-Ligand lnteractions
(2015-09-03)
During the past decade the effects of macromolecular crowding on reaction pathways is gaining in prominence. The stress is to move out of the realms of ideal solution studies and make conceptual modifications that consider ...
Stringent Response In Mycobacteria: Molecular Dissection Of Rel
(2007-11-29)
Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms. Such changes generate a quick and suitable response, which guides the physiology of bacteria. Stringent response ...
Lithium Exposure Induced Changes At Glutamatergic Synapses In Hippocampal Neurons- Insights From In Vitro Electrophysiology And Imaging Studies
(2016-11-15)
Lithium is a drug used to treat mood disorders and also has many side effects, including central nervous system (CNS) complications (such as cognitive dulling), associated with its use. The mechanism of its action still ...