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Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides
(2018-06-23)
Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
Structural Feature of Prokaryotic Promoters and their Role in Gene Expression
(2018-05-14)
Transcription initiation is an important step in the process of gene regulation in prokaryotes. Promoters are stretches of DNA sequence that are present in the upstream region of transcription start sites (TSSs), where RNA ...
Structural Investigations Of Sugar-Binding And Multivalency In Peanut Lectin
(2009-03-04)
Starting with the structure analysis of ConA in the 70s, the crystal structures of hundreds of different lectins and their carbohydrate complexes have been determined. Lectins, multivalent carbohydrate-binding proteins ...
Structural and Related Studies on Mycobacterial RecA and LexA
(2018-06-18)
Genetic material of bacteria is subject to damage due to multitudinous factors, both extrinsic and intrinsic in origin. Mechanisms for the maintenance of genomic integrity are thus essential for a bacterium to survive. ...
Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK
(2018-07-28)
A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host ...
Development of a Selective Cell-Permeable Protein Phosphatase 1 Inhibitor
(2018-07-10)
Selective ‘super-specific’ inhibitors of Protein Phosphatase 1 (PP1) are not available. Several natural product toxins possessing marginal selectivity between PP1 and the closely related Protein Serine/Threonine Phosphatase ...
Genome-Wide And Structural Analyses Of Protein Kinase Superfamily
(2010-04-12)
A signal transduction process refers to chain of highly regulated biochemical steps which results in the transfer of signal in response to a stimulus in the extracellular environment to the intracellular compartments such ...
Functionally Interacting Proteins : Analyses And Prediction
(2016-05-04)
Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where the interacting proteins physically ...
Structure Function Relationship In Tryptophanyl tRNA Synthetase Through MD Simulations & Quantum Chemical Studies On Unusual Bonds In Biomolecules
(2010-10-21)
Biological processes are so complicated that to understand the mechanisms underlying the functioning of biomolecules it is inevitable to study them from various perspectives and with a wide range of tools. Understanding ...