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Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes
(2018-07-04)
Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity with respect to the reaction catalyzed. Cellular activities depend ...
Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes
(2018-07-23)
Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among ...
In Silico Perspectives on RNA Structures Modulating Viral Gene Expression and Mechanics of tRNA Transport
(2018-07-19)
The repertoire of cellular functions mediated by Ribonucleic acid (RNA) molecules have expanded considerably during the last two decades. The role played by RNA in controlling and regulating gene expression in ...
Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides
(2018-06-23)
Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
Studies on NMPylase and Valine Catabolism Enzymes from Mycobacterium
Post-translational modifications constitute an important arm of the regulatory mechanism in mammalian cells. Therefore, bacterial pathogens, which thrive by mimicking the host cell signaling, are proving to be difficult ...
Structural Studies on Sesbania Mosaic Virus Protease Domain and Plasmodium Falciparum Hypoxanthine Quanine Phosphoribosyl Transferase and Triosephosphate Isomerase
X-ray crystallography is a powerful tool to obtain atomic resolution details on the three-dimensional structure of biological macromolecules. Crystallographic techniques find wide applications in understanding macromolecular ...
Role of an RNA Polymerase Interacting Protein, MsRbpA, from Mycobacterium smegmatis in Phenotypic Tolerance to Rifampicin
Rifampicin is a non-competitive inhibitor of bacterial RNA polymerase (RNAP). The knowledge about the mechanism of action of this drug has emanated from the genetic and the biochemical studies carried out on Escherichia ...
Protein Structure and Mutant Phenotype Prediction from Analysis of Mutant Libraries by Deep Sequencing
Proteins play a central role in all the biological processes. The immense diversity in protein structures and functions despite similar underlying composition is intriguing. The work presented in this thesis aims to provide ...
Role of RNA Polymerase ω Subunit in Metabolism and Stress Response
RNA polymerase (RNAP) is the key enzyme in transcription and it is a multi-subunit enzyme made up of alpha, beta, beta prime and omega subunit in the stoichiometry of α2ββω. Except for the smallest subunit ω (rpoZ), all ...
Role of Second (p)ppGpp Synthetase MS_RHII-RSD in Mycobacterium smegmatis
Adaptation to a rapidly fluctuating environment is the key to the survival of an organism. Bacteria sense and respond to stress by an overall reprogramming of the cellular processes to shut down the energy-consuming processes ...