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Designed β-Hairpin, β-Sheet And Mixed α-β Structures In Synthetic Peptides
(Indian Institute of Science, 2007-03-16)
Synthetic construction of protein molecules has been widely pursued over the last two decades. A primary goal behind de novo protein design has been to build minimal systems by capturing the essential features of protein ...
Endotoxin Peptide/Protein Interactions: Thermodynamic And Kinetic Analysis
(Indian Institute of Science, 2006-05-15)
Endotoxin or Lipopolysaccharide (LPS) is the invariant structural component of gram negative bacterial outer membranes and is the chief causative factor of Sepsis or endotoxic shock. Sepsis is a syndrome that has very high ...
Analysis Of Protein Evolution And Its Implications In Remote Homology Detection And Function Recognition
(2009-07-22)
One of the major outcomes of a genome sequencing project is the availability of amino acid sequences of all the proteins encoded in the genome of the organism concerned. However, most commonly, for a substantial proportion ...
Non-repetitive Structures In Proteins : Effects Of Side-chain And Solvent Interactions With The Backbone
(Indian Institute of Science, 2006-05-12)
The work presented in this thesis deals with the analysis of protein crystal structures with an emphasis on the stereochemical aspects of the folded conformation of proteins. The various analyses described have been performed ...
Aromatic Interactions In Peptides : Designed Helices And β-Hairpins
(2009-04-15)
Design of complex protein folds requires complete understanding of the stereochemical principles that govern polypeptide chain folding. Extensive studies on design and synthesis of specific secondary structures like ...
Structural Studies On Three Pyridoxal-5'-Phosphate Dependent Enzymes : N-Acetylornithine Aminotransferase, Serine Hydroxymethyltransferase And Diaminopropionate Ammonia Lyase
(2009-09-02)
Pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, is a cofactor for many enzymes involved in the metabolism of amino acids, amino acid derived metabolites and some amino sugars. PLP is one of the most versatile ...
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)
Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ...
Structural Studies On Basic Winged Bean Agglutinin
(2009-07-03)
The journey of structural studies on lectins, starting with ConA in the 70s, has crossed many milestones. Lectins, multivalent carbohydrate-binding proteins of non-immune origin, specifically bind diverse sugar structures. ...
Computer Modeling and Molecular Dynamics Simulation Of Angiogenins And Its Ligand Bound Complexes
(Indian Institute of Science, 2006-05-04)
Computational structural biology
Even with rapid advances in structure determination methods, there is a long gap to be bridged between the number of proteins that have been sequenced and the number whose three-dimensional ...
Mass Spectrometric Sequencing Of Acyclic And Cyclic Peptides
(2009-05-18)
Elucidation of the primary structure of peptides and proteins de novo by mass spectrometry (MS) has become possible with the advent of tandem MS methods. The most widely used chemical method due to Edman (Edman & Begg, ...