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Now showing items 101-110 of 152
Mechanistic And Regulatory Aspects Of The Mycobacterium Tuberculosis Dephosphocoenzyme A Kinase
(2013-09-11)
The current, grim world-TB scenario, with TB being the single largest infectious disease
killer, warrants a more effective approach to tackle the deadly pathogen, Mycobacterium
tuberculosis. The deadly synergy of this ...
Computer Modelling Studies On DNA Triple Helices
(2013-07-22)
Structure Analysis Of Plant Lectin Domains
(2014-04-07)
Lectins are multivalent carbohydrate binding proteins that specifically recognise diverse sugar structures and mediate a variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein ...
Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
(2013-08-30)
Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ...
Metabolic Adaptation For Utilization Of Short-Chain Fatty Acids In Salmonella Typhimurium : Structural And Functional Studies On 2-methylcitrate Synthase, Acetate And Propionate Kinases
(2013-08-22)
Three-dimensional structures of proteins provide insights into the mechanisms of macromolecular assembly, enzyme catalysis and mode of activation, substrate-specificity, ligand-binding properties, stability and dynamical ...
Molecular Characterization c-di-GMP Signalling In Mycobacterium Smegmatis
(2014-07-17)
Bacterial stationary phase is an interesting biological system to study, as the organism undergoes several metabolic changes during this period and new molecules are generated to support its survival. The stationary phase ...
Structure Analysis Of FabI And FabZ Enzymes Of The Fatty Acid Biosynthesis Pathway Of Plasmodium Falciparum
(2013-08-30)
The emergence of drug resistant strains of Plasmodium has given a new face to the old disease, malaria. One of the approaches is to block metabolic pathways of the pathogen. The current thesis describes the X-ray ...
Computational And Experimental Studies On Protein Structure, Stability And Dynamics
(2014-08-18)
The work in this thesis focuses on the study of three main aspects of proteins, viz, Protein structure, stability, and dynamics. Chapter 1 is a general introduction to the topics studied in this thesis. Chapter 2 deals ...
Structural Studies Of E. Coli Thioredoxin And P. Falciparum Triosephosphate Isomerase By NMR And Computational Methods
(2014-05-21)
To unravel the mysteries of complex biological processes carried out by biomolecules it is necessary to adopt a multifaceted approach, which involves employing a wide variety of tools both computational and experimental. ...